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The Effect of Hypercholestrolemia on Calf Muscle Hemoglobin Oxygen Saturation in Patients With Intermittent Claudication

Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Polly S. Montgomery, MS

CMRI Metabolic Research Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Kristy J. Scott, BS

CMRI Metabolic Research Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Steve M. Blevins, MD

General Internal Medicine Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Thomas L. Whitsett, MD

Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Andrew W. Gardner, PhD

CMRI Metabolic Research Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, andrew-gardner{at}ouhsc.edu

The purpose was to compare calf muscle hemoglobin oxygen saturation and exercise performance in hypercholesterolemic and normocholesterolemic patients with peripheral arterial disease. Hypercholesterolemic and normocholesterolemic patients had similar ankle/ brachial index (0.72 ± 0.24 vs 0.79 ± 0.28, [mean ± SD]; P = .334). Hypercholesterolemic patients had shorter initial claudication distance (214 ± 168 m vs 331 ± 185 m, P = .026), absolute claudication distance (391 ± 219 m vs 549 ± 211 m, P = .035), and lower calf muscle hemoglobin oxygen saturation at the occurrence of initial claudication distance (27 ± 21% vs 39 ± 20%; P = .013), and absolute claudication distance (26 ± 21% vs 36 ± 21%; P = .021). Hypercholesterolemia is associated with shorter walking distances and calf muscle hemoglobin oxygen saturation during exercise in patients limited by intermittent claudication.

Key Words: exercise • intermittent claudication • hemoglobin oxygen saturation • peripheral arterial disease • statins

This version was published on October 1, 2008

Angiology, Vol. 59, No. 5, 534-541 (2008)
DOI: 10.1177/0003319707308728


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