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Angiology
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Article

Improvement in Circulation and in Cardiovascular Risk Factors With a Proprietary Isotonic Bioflavonoid Formula OPC-3®

Maria R. Cesarone, MD, Andrea Di Renzo, MD, Silvia Errichi, MD, Frank Schönlau, PhD, James L. Wilmer, PhD, and Julian Blumenfeld, MD*

NutraMetrix, Division of Market America

* To whom correspondence should be addressed. E-mail: julianb{at}nutrametrix.com.


  Abstract
This study investigated the efficacy of isotonic bioflavonoid supplementation, OPC-3 on 61 individuals presenting with risk factors meeting the criteria for metabolic syndrome. Subjects were supplemented with a proprietary isotonic bioflavonoid OPC-3 or placebo over 2 months. Plasma oxidative stress status was significantly lowered by 10.1% with OPC-3. All major cardiovascular risk factors were improved with blood pressure, total cholesterol, and fasting blood glucose lowered. OPC-3 significantly improved endothelial function as evaluated by increased vasorelaxation in reactive hyperemia and enhanced diastolic carotid artery flow. Cardiac ultrasound scanning revealed a significant increase of left ventricular ejection fraction. Skin microcirculation was enhanced, and better tissue perfusion led to significantly increased transcutaneous oxygen partial pressure and decreased <I>p</I>CO2. With OPC-3 a dramatic and significant plasma C-reactive protein decrease by 52.1% occurred. Individuals may improve key cardiovascular risk factors by daily supplementation with the bioflavonoid OPC-3 as an important part of a healthier lifestyle.

First published on July 15, 2008, doi:10.1177/0003319708321801

Angiology 2008;59:408.

A more recent version of this article appeared on August 1, 2008

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