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Baseline ICAM-1 and VCAM-1 Are Increased in Initially Healthy Middle-Aged Men Who Develop Cardiovascular Disease During 6.6 Years of Follow-Up
Caroline Schmidt*,
Johannes Hulthe,
and
Björn Fagerberg, MD, PhD
* To whom correspondence should be addressed. E-mail: caroline.schmidt{at}wlab.gu.se.
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Abstract |
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The objective of the present study was to investigate if there was a difference in baseline serum concentrations of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) between groups with and without cardiovascular events during a mean follow-up of 6.6 years in a group of initially healthy 58-year-old men. A further aim was to examine if high serum concentrations of ICAM-1 and VCAM-1 were associated with carotid and femoral artery plaque occurrence, separately. Men with cardiovascular events during follow-up had higher median serum ICAM-I and VCAM-I than those without events (P < .05). The median of serum ICAM-I and VCAM-1 in the event group was used as the cutoff level, and in those with ICAM-1 and VCAM-1 above the cutoff value, there was an increased risk of having a plaque in the femoral artery (OR = 2.8, 95% CI = 1.8-4.3; and OR = 1.6, 95% CI = 1.1-2.5, respectively).
First published on May 25, 2008, doi:10.1177/0003319708316899
Angiology 2009;60:108.
A more recent version of this article appeared on February 1, 2009
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