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Ceruloplasmin is a Better Predictor of the Long-Term Prognosis Compared With Fibrinogen, CRP, and IL-6 in Patients With Severe Unstable Angina
Antonios Ziakas*,
Stavros Gavrilidis,
Efthimia Souliou,
george Giannoglou,
Ioannis Stiliadis,
Haralampos Karvounis,
George Efthimiadis,
Sotirios Mochlas,
Apostolos Hatzitolios,
Christos Savopoulos,
Ifigenia Pidonia,
and
George parxaridis
* To whom correspondence should be addressed. E-mail: aziakas{at}med.auth.gr.
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Abstract |
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Background. We investigated the time course and prognostic value of fibrinogen (Fib), C-reactive protein (CRP), interleukin-6 (IL-6), and ceruloplasmin (CP) in patients with severe unstable angina. Methods. All 4 substances were measured on admission and after 6, 12, 24, 48, and 72 hours, and after 7 days and 6 months in 40 patients with Braunwald’s classification class IIIB unstable angina. Results. All recorded substances increased significantly; 15 patients had cardiovascular events during hospitalization and 11 patients during follow-up. The time course and the mean values of Fib, CRP, and IL-6 were similar in patients with and without complications both during hospitalization and follow-up. However, CP levels from 6 hours until 6 months were significantly higher in patients with complications during follow-up (P< .05). Conclusions. Fib, CRP, IL-6, and CP levels alter in patients with severe unstable angina. However, only CP levels were related to 12-month follow-up prognosis.
First published on April 2, 2008, doi:10.1177/0003319708314249
Angiology 2009;60:50.
A more recent version of this article appeared on February 1, 2009
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