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Association Between Protein-Bound Sialic Acid and High-Sensitivity C-Reactive Protein in Essential Hypertension: A Possible Indication of Underlying Cardiovascular Risk
Sathiyapriya Viswanathan,
Selvaraj Nambiar,
Nandeesha Hanumanthappa,
Bobby Zachariah*,
Aparna Agrawal,
and
Pavithran Purushothaman
* To whom correspondence should be addressed. E-mail: zacbobby{at}yahoo.com.
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Abstract |
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The aim of this study was to examine the possible alteration in the levels of C-reactive protein, protein-bound sialic acid, and other lipid risk factors in newly diagnosed essential hypertensive subjects. In all, 56 hypertensive and 33 normotensive male subjects were enrolled in the study. Lipid profile, C-reactive protein, apolipoprotein-B, and protein-bound sialic acid were estimated in both the groups. Total cholesterol, triglyceride, low-density lipoprotein–cholesterol, C-reactive protein, apolipoprotein-B, and protein-bound sialic acid were significantly increased in patients with essential hypertension. Correlation analysis revealed a significant association between the protein-bound sialic acid with mean arterial pressure, C-reactive protein, and low-density lipoprotein–cholesterol. The findings of the present study suggest that in essential hypertension there is an association between protein-bound sialic acid and C-reactive protein, which reflects the clustering of cardiovascular risk factors in these patients.
First published on April 2, 2008, doi:10.1177/0003319708314246
Angiology 2009;59:721.
A more recent version of this article appeared on January 1, 2009
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