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In-Stent Stenosis: Potential Role of Increased Oxidative Stress and Glutathione-Linked Detoxification Mechanisms
Praphul Misra, MD,
Pratap C. Reddy, MD,
Deepti Shukla, MD,
Gloria C. Caldito, PhD,
Lakshminarayan Yerra, MD,
and
Tak Yee Aw, PhD*
Louisiana State University Health Sciences Center
* To whom correspondence should be addressed. E-mail: taw{at}lsuhsc.edu.
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Abstract |
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This study was designed to determine whether red-cell oxidative stress status and antioxidant enzyme levels can serve as markers in patients predisposed to in-stent stenosis. Blood was collected from patient groups undergoing coronary angiography for chest pain evaluation, namely, group A (without coronary artery disease), group B (previous coronary stents without in-stent stenosis), and group C (previous coronary stents with in-stent stenosis). Thiobarbituric acid reactive substances (measure of lipid peroxidation), glutathionelinked detoxification enzymes, catalase, and superoxide dismutase were determined. Compared with group A, patients in group C showed increased lipid peroxidation products and glutathione-S-transferase but decreased glutathione peroxidase and glutathione reductase activities. Results in group B patients were intermediate between those of groups A and C with significant decreases in glutathione peroxidase versus controls. In-stent stenosis is associated with significant increase in lipid peroxidation and attenuated glutathione-linked detoxification enzymes, consistent with oxidative stress.
First published on May 25, 2008, doi:10.1177/0003319707309651
Angiology 2008;59:469.
A more recent version of this article appeared on August 1, 2008
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