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Angiology
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Article

Secondary Prevention of Arterial Disease in Very Elderly People: Results From a Prospective Registry (FRENA)

Luciano Lopez-Jimenez, PhD, Miguel Camafort, MD, Gregorio Tiberio, MD, Jose Antonio Carmona, MD, Carlos Guijarro, MD, Francisco Martinez-Penalver, MD, and Manuel Monreal, PhD*

Servicio de Medicina Interna

* To whom correspondence should be addressed. E-mail: mmonreal.germanstrias{at}gnecat.net.


  Abstract
There is little information on the effectiveness of secondary prevention interventions in very elderly patients. In this article, the incidence of major cardiovascular events during a 12-month follow-up period in a series of consecutive patients with coronary, cerebrovascular, or peripheral artery disease is analyzed. As of October 2006, 1264 patients had been enrolled. Of these, 324 (26%) were ≥75 years of age. Their incidence rate of 22 events per 100 patient-years (95% CI, 17-28) was over 2-fold the 7.9 (95% CI, 6.2-10) found in those <75 years of age. Among them, only chronic heart failure and diabetes were independently associated with an increased risk for major events, whereas the use of angiotensin II antagonists was associated with a lower risk. Patients ≥75 years of age had an over 2-fold higher incidence of major cardiovascular events. The use of angiotensin II antagonists was associated with a lower risk.

First published on April 2, 2008, doi:10.1177/0003319707309299

Angiology 2008;59:427.

A more recent version of this article appeared on August 1, 2008

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