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The Effect of Hypercholestrolemia on Calf Muscle Hemoglobin Oxygen Saturation in Patients With Intermittent Claudication

General Clinical Research Center

^* To whom correspondence should be addressed. E-mail: azharafaq{at}gmail.com.

	Abstract

The purpose was to compare calf muscle hemoglobin oxygen saturation and exercise performance in hypercholesterolemic and normocholesterolemic patients with peripheral arterial disease. Hypercholesterolemic and normocholesterolemic patients had similar ankle/ brachial index (0.72 ± 0.24 vs 0.79 ± 0.28, [mean ± SD]; P = .334). Hypercholesterolemic patients had shorter initial claudication distance (214 ± 168 m vs 331 ± 185 m, P = .026), absolute claudication distance (391 ± 219 m vs 549 ± 211 m, P = .035), and lower calf muscle hemoglobin oxygen saturation at the occurrence of initial claudication distance (27 ± 21% vs 39 ± 20%; P = .013), and absolute claudication distance (26 ± 21% vs 36 ± 21%; P = .021). Hypercholesterolemia is associated with shorter walking distances and calf muscle hemoglobin oxygen saturation during exercise in patients limited by intermittent claudication.

First published on April 2, 2008, doi:10.1177/0003319707308728

Angiology 2008;59:534.

A more recent version of this article appeared on October 1, 2008


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