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Angiology
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Article

Risk Stratification of Apolipoprotein B, A1, and B/AI Ratio on the Prevalence of Metabolic Syndrome: The ATTICA Study

Christos Pitsavos, Demosthenes B. Panagiotakos*, John Skoumas, Labros Papadimitriou, and Christodoulos Stefanadis

* To whom correspondence should be addressed. E-mail: d.b.panagiotakos{at}usa.net.


  Abstract
We investigated the association of apolipoproteins AI and B in relation to the prevalence of metabolic syndrome in a random sample of cardiovascular disease– free adults from the ATTICA study (1,514 men, aged 18-87 y; 1,528 women, aged 18-89 y). Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. The prevalence of metabolic syndrome was 25% in men and 15% in women (P < .001). Using the area under the Receiver Operation Characteristic curve, apolipoprotein B/AI was the best diagnostic marker of metabolic syndrome, the optimal discriminating cut-off value of this ratio was 0.72 (sensitivity 74%, specificity 67%), and individuals with apolipoprotein B/AI ratio greater than 0.74 had 3.29 times higher odds of having metabolic syndrome (95% confidence interval: 2.56-4.21) after adjusting for potential confounders.

First published on April 2, 2008, doi:10.1177/0003319707307273

Angiology 2008;59:335.

A more recent version of this article appeared on July 1, 2008

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