Angiology

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

http://mc.manuscriptcentral.com/ang

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Al-Barjas, H. S.
Right arrow Articles by Scott, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Al-Barjas, H. S.
Right arrow Articles by Scott, J. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Angiology, Vol. 57, No. 5, 607-614 (2006)
DOI: 10.1177/0003319706293132

Raised Plasma Fibrinogen Concentration in Patients With Abdominal Aortic Aneurysm

Hamad S. Al-Barjas, MD

Academic Unit of Molecular Vascular-Medicine, the LIGHT Laboratories, University of Leeds, Leeds, UK, dralbarjas{at}yahoo.co.uk

Robert Ariëns, PhD

Academic Unit of Molecular Vascular-Medicine, the LIGHT Laboratories, University of Leeds, Leeds, UK

Peter Grant, MD

Academic Unit of Molecular Vascular-Medicine, the LIGHT Laboratories, University of Leeds, Leeds, UK

Julian A. Scott, MD

Academic Unit of Molecular Vascular-Medicine, the LIGHT Laboratories, University of Leeds, Leeds, UK

A feature associated with abdominal aortic aneurysms (AAA) is the presence of intraluminal thrombi (ILT). Elevated plasma fibrinogen concentrations predict a greater risk of thrombosis. Therefore, the authors assessed the relationship between fibrinogen levels, AAA size, and ILT. An age- and sex-matched case-control study was conducted. Demographic data and plasma samples were obtained from 110 patients with AAA and 110 controls. All subjects had an abdominal ultrasound scan to determine the size of the aneurysm and the percentage of the ILT occupying the lumen. Plasma fibrinogen concentrations were measured by the Clauss method. Fibrinogen concentrations were significantly higher in patients with AAA than in controls (median: 2.89 vs 2.53 g/L; p<0.01). Patients with AAA who were current smokers had a larger median AAA size (4.50 vs 4.30 cm; p<0.04) and greater percentage of the ILT (40% vs 30%) than those who did not smoke. Fibrinogen was positively correlated with AAA size (r =0.323; p<0.01) and the percentage of ILT occupying the lumen (r =0.358; p<0.05). Fibrinogen levels were higher in the AAA group. The authors also demonstrated positive correlations between the AAA size, ILT, and fibrinogen concentration. Smoking was associated with larger aneurysms and ILT. Fibrinogen may be a useful marker to monitor the progression of AAA.

References

  • Wanhainen A, Bergqvist D, Boman K, et al: Risk factors associated with abdominal aortic aneurysm: A population-based study with historical and current data. J Vasc Surg 41: 390-396, 2005.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Grange JJ, Davis V, Baxter BT: Pathogenesis of abdominal aortic aneurysm: An update and look toward the future. Cardiovasc Surg 5: 256-265, 1997.[CrossRef][Medline] [Order article via Infotrieve]
  • Wassef M, Baxter BT, Chisholm RL, et al: Pathogenesis of abdominal aortic aneurysms: A multidisciplinary research program supported by the National Heart, Lung, and Blood Institute. J Vasc Surg 34: 730-738, 2001.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Thompson RW, Geraghty PJ, Lee JK: Abdominal aortic aneurysms: Basic mechanisms and clinical implications. Curr Probl Surg 39: 110-230, 2002.[CrossRef][Medline] [Order article via Infotrieve]
  • Di Martino ES, Vorp DA: Effect of variation in intraluminal thrombus constitutive properties on abdominal aortic aneurysm wall stress. Ann Biomed Eng 31: 804-809, 2003.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Satta J, Laara E, Juvonen T: Intraluminal thrombus predicts rupture of an abdominal aortic aneurysm. J Vasc Surg 23: 737-739, 1996.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Wolf YG, Thomas WS, Brennan FJ, et al: Computed tomography scanning findings associated with rapid expansion of abdominal aortic aneurysms. J Vasc Surg 20: 529-535, 1994.[ISI][Medline] [Order article via Infotrieve]
  • Adam DJ, Haggart PC, Ludlam CA, et al: Hemostatic markers before operation in patients with acutely symptomatic nonruptured and ruptured infrarenal abdominal aortic aneurysm. J Vasc Surg 35: 661-665, 2002.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Yamazumi K, Ojiro M, Okumura H, et al: An activated state of blood coagulation and fibrinolysis in patients with abdominal aortic aneurysm. Am J Surg 175: 297-301, 1998.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Heinrich J, Balleisen L, Schulte H, et al: Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men. Arterioscler Thromb 14: 54-59, 1994.[Abstract/Free Full Text]
  • Smith FB, Lee AJ, Fowkes FG, et al: Hemostatic factors as predictors of ischemic heart disease and stroke in the Edinburgh Artery Study. Arterioscler Thromb Vasc Biol 17: 3321-3325, 1997.[Abstract/Free Full Text]
  • Smith FB, Lee AJ, Hau CM, et al: Plasma fibrinogen, haemostatic factors and prediction of peripheral arterial disease in the Edinburgh Artery Study. Blood Coagul Fibrinolysis 11: 43-50, 2000.[ISI][Medline] [Order article via Infotrieve]
  • Baker JD, Rutherford RB, Bernstein EF, et al: Suggested standards for reports dealing with cerebrovascular disease. Subcommittee on Reporting Standards for Cerebrovascular Disease, Ad Hoc Committee on Reporting Standards, Society for Vascular Surgery/North American Chapter, International Society for Cardiovascular Surgery. J Vasc Surg 8: 721-729, 1988.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Carter AM, Mansfield MW, Stickland MH, et al: Beta-fibrinogen gene-455 G/A polymorphism and fibrinogen levels. Risk factors for coronary artery disease in subjects with NIDDM. Diabetes Care 19: 1265-1268, 1996.[Abstract]
  • Lindblad B, Borner G, Gottsater A: Factors associated with development of large abdominal aortic aneurysm in middle-aged men. Eur J Vasc Endovasc Surg 30: 346-352, 2005.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Singh K, Bonaa KH, Jacobsen BK, et al: Prevalence of and risk factors for abdominal aortic aneurysms in a population-based study: The Tromso Study. Am J Epidemiol 154: 236-244, 2001.[Abstract/Free Full Text]
  • Shindo S, Matsumoto H, Kubota K, et al: Is the size of an abdominal aortic aneurysm associated with coagulopathy? World J Surg [Epub ahead of print], 2005.
  • Jones KG, Brull DJ, Brown LC, et al: Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation 103: 2260-2265, 2001.[Abstract/Free Full Text]
  • Bown MJ, Nicholson ML, Bell PR, et al: The systemic inflammatory response syndrome, organ failure, and mortality after abdominal aortic aneurysm repair. J Vasc Surg 37: 600-606, 2003.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Satoh H, Nakamura M, Satoh M, et al: Expression and localization of tumour necrosis factor-alpha and its converting enzyme in human abdominal aortic aneurysm. Clin Sci (Lond) 106: 301-306, 2004.[Medline] [Order article via Infotrieve]
  • Reinhart WH: Fibrinogen—marker or mediator of vascular disease? Vasc Med 8: 211-216, 2003.[Abstract/Free Full Text]
  • Mbachu EM, Klein LV, Rubin BB, et al: A monoclonal antibody against cytokine-induced neutrophil chemoattractant attenuates injury in the small intestine in a model of ruptured abdominal aortic aneurysm. J Vasc Surg 39: 1104-1111, 2004.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms. The UK Small Aneurysm Trial Participants. Lancet 352: 1649-1655, 1998.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Ashton HA, Buxton MJ, Day NE, et al: The Multi-centre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: A randomised controlled trial. Lancet 360: 1531-1539, 2002.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Brady AR, Fowkes FG, Thompson SG, et al: Aortic aneurysm diameter and risk of cardiovascular mortality. Arterioscler Thromb Vasc Biol 21: 1203-1207, 2001.[Abstract/Free Full Text]
  • Fatah K, Silveira A, Tornvall P, et al: Proneness to formation of tight and rigid fibrin gel structures in men with myocardial infarction at a young age. Thromb Haemost 76: 535-540, 1996.[ISI][Medline] [Order article via Infotrieve]
  • Mills JD, Ariens RA, Mansfield MW, et al: Altered fibrin clot structure in the healthy relatives of patients with premature coronary artery disease. Circulation 106: 1938-1942, 2002.[Abstract/Free Full Text]
  • Wierzbicki AS, Mikhailidis DP, Wray R, et al: Statinfibrate combination: Therapy for hyperlipidemia: A review. Curr Med Res Opin 19: 155-168, 2003.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Ezzati M, Henley SJ, Thun MJ, et al: Role of smoking in global and regional cardiovascular mortality. Circulation 112: 489-497, 2005.[Abstract/Free Full Text]
  • Smoking, lung function and the prognosis of abdominal aortic aneurysm. The UK Small Aneurysm Trial Participants. Eur J Vasc Endovasc Surg 19: 636-642, 2000.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Tsiara S, Elisaf M, Mikhailidis DP: Influence of smoking on predictors of vascular disease. Angiology 54: 507-530, 2003.[ISI][Medline] [Order article via Infotrieve]
  • Hu CH, Harris JE, Davie EW, et al: Characterization of the 5'-flanking region of the gene for the alpha chain of human fibrinogen. J Biol Chem 270: 28342-28349, 1995.[Abstract/Free Full Text]
  • Humphries SE, Luong LA, Montgomery HE, et al: Gene-environment interaction in the determination of levels of plasma fibrinogen. Thromb Haemost 82: 818-825, 1999.[ISI][Medline] [Order article via Infotrieve]
  • Wilmink TB, Quick CR, Day NE: The association between cigarette smoking and abdominal aortic aneurysms. J Vasc Surg 30: 1099-1105, 1999.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Jorenby DE, Leischow SJ, Nides MA, et al: A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. N Engl J Med 340: 685-691, 1999.[Abstract/Free Full Text]
  • Joseph AM, Norman SM, Ferry LH, et al: The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. N Engl J Med 335: 1792-1798, 1996.[Abstract/Free Full Text]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?



This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Al-Barjas, H. S.
Right arrow Articles by Scott, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Al-Barjas, H. S.
Right arrow Articles by Scott, J. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?