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Marked Decrease of Plasma VEGF After Implantation of Autologous Bone Marrow Mononuclear Cells in a Patient with Critical Limb Ischemia

A Case Report

Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan, takuya-o{at}med.niigata-u.ac.jp

Kiminori Kato, MD

Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Hirofumi Sanada, MD

Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Yashiro Makiyama, MD

Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Takashi Saigawa, MD

Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Satoru Souda, MD

Division of Endocrinology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Shigeo Hashimoto, MD

Division of Hematology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Tatsuo Furukawa, MD

Division of Hematology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Ken Toba, MD

Division of Hematology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Makoto Kodama, MD

Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Hiroshi Fujiwara, MD

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Osamu Namura, MD

Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Junichi Hayashi, MD

Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Nobuhiko Yoshimura, MD

Radiation Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

Yoshifusa Aizawa

Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Japan

The authors performed autologous bone marrow mononuclear cells implantation (BMI) in a 79-year-old man with critical limb ischemia. After BMI, the resting pain of the ischemic leg improved gradually. They measured the plasma concentrations of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and serum hepatocyte growth factor (HGF) in the blood from bilateral femoral veins. Before BMI, the plasma VEGF and bFGF concentrations were much greater in the ischemic leg than in the other lower limb, but decreased to the same concentrations as those in the contralateral lower extremity after BMI. The large concentrations of the angiogenic factors VEGF and bFGF in plasma indicate the severity and extent of the leg ischemia. BMI resulted in lower levels of VEGF and bFGF, and this fall is the hallmark of the effectiveness of BMI in the treatment of peripheral artery disease.

References

• Tateishi E, Matsubara H, Murohara T, et al: Therapeutic angiogenesis for patients with limb ischemia by autologous transplantation of bone-marrow cells. Lancet 360:427-435, 2002.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Fujita S, Hakoshima A, Fujiwara Y, et al: Physical training does not increase VEGF in skeletal muscle of rat with peripheral arterial insufficiency. J Jpn Coll Angiol 43:59-63, 2003.

Angiology, Vol. 57, No. 2, 235-239 (2006)
DOI: 10.1177/000331970605700216


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Ozawa, T. Articles by Aizawa, Y. Search for Related Content PubMed PubMed Citation Articles by Ozawa, T. Articles by Aizawa, Y. Social Bookmarking                         What's this?