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Noninvasive Tissue Characterization of Coronary Arterial Plaque by 16-Slice Computed Tomography in Acute Coronary Syndrome

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan

Takanori Yasu, MD

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan, tyasu{at}omiya.jichi.ac.jp

Yasuyuki Kobayashi, MD

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan

Takuji Katayama, MD

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan

Yoshitaka Sugawara, MD

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan

Hiroshi Funayama, MD

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan

Yousuke Takagi, MD

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan

Nahoko Ikeda, MD

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan

Takeshi Ishida, MD

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan

Yoshio Tsuruya, MD

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan

Norifumi Kubo, MD

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan

Muneyasu Saito, MD

First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan

Noninvasive characterization of coronary plaques is challenging for cardiologists. The authors’ goal was to explore the clinical feasibility of newly developed 16-slice computed tomography (CT) in tissue characterization of coronary arterial plaques in patients with acute coronary syndrome. Sixteen patients with acute coronary syndrome underwent 16-slice CT (Aquillion, Toshiba) and coronary arteriography with intravascular ultrasound (IVUS) within 7 days. Twenty-three plaques were classified by IVUS according to plaque echogenicity: 6 soft plaques, 11 intermediate plaques, and 6 calcified plaques. Mean (±SD) CT numbers (Hounsfield units [HU]) of these 3 types of plaques were 50.6 ±14.8 HU, 131 ±21.0 HU, and 721 ±231 HU, respectively. Sixteen-slice CT facilitates noninvasive tissue characterization of coronary arterial plaques.

References

• Rioufol G, Finet G, Ginon I, et al: Multiple atherosclerotic plaque rupture in acute coronary syndrome: A three-vessel intravascular ultrasound study. Circulation 106:804-808, 2002.[Abstract/Free Full Text]
• Asakura M, Ueda Y, Yamaguchi O, et al: Extensive development of vulnerable plaques as a pan-coronary process in patients with myocardial infarction: An angioscopic study. J Am Coll Cardiol 37:1284-1288, 2001.[Abstract/Free Full Text]
• von Birgelen C, Klinkhart W, Mintz GS, et al: Plaque distribution and vascular remodeling of ruptured and nonruptured coronary plaques in the same vessel: An intravascular ultrasound study in vivo. J Am Coll Cardiol 37:1864-1870, 2001.[Abstract/Free Full Text]
• Saito S, Yamagishi M, Takayama T, et al: Plaque morphology at coronary sites with focal spasm in variant angina. Circ J 67:1041-1045, 2002.[CrossRef]
• Yamagishi M, Terashima M, Awano K, et al: Morphology of vulnerable coronary plaque: Insights from follow-up of patients examined by intravascular ultrasound before an acute coronary syndrome. J Am Coll Cardiol 35:106-111, 2000.[Abstract/Free Full Text]
• Tanaka A, Kawarabayashi T, Taguchi H, et al: Use of preintervention intravascular ultrasound in patients with acute myocardial infarction. Am J Cardiol 89: 257-261, 2002.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Gyongyosi M, Yang P, Hassan A, et al: Intravascular ultrasound predictors of major adverse cardiac events in patients with unstable angina. Clin Cardiol 23: 507-515, 2000.[Web of Science][Medline] [Order article via Infotrieve]
• Fayad ZA: Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI. Neuroimaging Clin North Am 12:461-471, 2002.
• Fayad ZA, Fuster V: Characterization of atherosclerotic plaques by magnetic resonance imaging. Ann NY Acad Sci 902:173-186, 2000.[Web of Science][Medline] [Order article via Infotrieve]
• Choi CJ, Kramer CM: MR imaging of atherosclerotic plaque. Radiol Clin North Am 40:887-898, 2002.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Schroeder S, Kopp AF, Baumbach A, et al: Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography. J Am Coll Cardiol 37:1430-1435, 2001.[Abstract/Free Full Text]
• Schoenhagen P, Tuzcu EM, Stillman AE, et al: Noninvasive assessment of plaque morphology and remodeling in mildly stenotic coronary segments: Comparison of 16-slice computed tomography and intravascular ultrasound. Coron Artery Dis 14:459-462, 2003.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Schroeder S, Flohr T, Kopp AF, et al: Accuracy of density measurements within plaques located in artificial coronary arteries by X-ray multislice CT: Results of a phantom study. J Comput Assist Tomogr 25:900-906, 2001.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Carrascosa PM, Capunay CM, Parodi JC, et al: General utilities of multislice tomography in the cardiac field. Herz 28:44-51, 2003.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Schroeder S, Kopp AF, Baumbach A, et al: Noninvasive detection of coronary lesions by multislice computed tomography: Results of the New Age pilot trial. Cathet Cardiovasc Interv 53:352-358, 2001.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Kopp AF, Schroeder S, Baumbach A, et al: Non-invasive characterisation of coronary lesion morphology and composition by multislice CT: First results in comparison with intracoronary ultrasound. Eur Radiol 11:1607-1611, 2001.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Schroeder S, Kopp AF, Ohnesorge B, et al: Virtual coronary angioscopy using multislice computed tomography. Heart 87:205-209, 2002.[Abstract/Free Full Text]
• Nieman K, van der Lugt A, Pattynama PM, et al: Noninvasive visualization of atherosclerotic plaque with electron beam and multislice spiral computed tomography. J Interv Cardiol 16:123-128, 2003.[Medline] [Order article via Infotrieve]
• Glassman AH, O’Connor CM, Califf RM, et al: Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA 288:701-709, 2002.[Abstract/Free Full Text]
• Athanasiadis A, Haase KK, Wullen B, et al: Lesion morphology assessed by preinterventional intravascular ultrasound does not predict the incidence of severe coronary artery dissections. Eur Heart J 19:870-878, 1998.[Abstract/Free Full Text]
• Schroeder S, Baumbach A, Haase KK, et al: Reduction of restenosis by vessel size-adapted percutaneous transluminal coronary angioplasty using intravascular ultrasound. Am J Cardiol 83:875-879, 1999.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Schroeder S, Baumbach A, Mahrholdt H, et al: The impact of untreated coronary dissections on acute and long-term outcome after intravascular ultra-sound-guided PTCA. Eur Heart J 21:137-145, 2000.[Abstract/Free Full Text]
• Schwartz GG, Olsson AG, Ezekowitz MD, et al: Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The MIRACL study: A randomized controlled trial. JAMA 285: 1711-1718, 2001.[Abstract/Free Full Text]
• Correia LC, Sposito AC, Lima JC, et al: Anti-inflammatory effect of atorvastatin (80 mg) in unstable angina pectoris and non-Q-wave acute myocardial infarction. Am J Cardiol 92:298-301, 2003.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Sasaki S, Nakagawa M, Nakata T, et al: Effects of pravastatin on exercise electrocardiography test performance and cardiovascular mortality and morbidity in patients with hypercholesterolemia. Circ J 66:47-52, 2002.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• de Feyter P, Mollet NR, Cadermartiri F, et al: MS-CT coronary imaging. J Interv Cardiol 16:465-468, 2003.[CrossRef][Medline] [Order article via Infotrieve]
• Sato Y, Kanmatsuse K, Inoue F, et al: Noninvasive coronary artery imaging by multislice spiral computed tomography. Circ J 67:107-111, 2003.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Nieman K, Cademartiri F, Lemos PA, et al: Reliable noninvasive coronary angiography with fast submillimeter multislice spiral computed tomography. Circulation 106:2051-2054, 2002.[Abstract/Free Full Text]
• Morgan-Hughes GJ, Marshall AJ, Roobottom C: Morphologic assessment of patent ductus arteriosus in adults using retrospectively ECG-gated multidetector CT. Am J Roentgenol 181:749-754, 2003.[Abstract/Free Full Text]
• Schwartzman D, Lacomis J, Wigginton WG: Characterization of left atrium and distal pulmonary vein morphology using multidimensional computed tomography. J Am Coll Cardiol 41:1349-1357, 2003.[Abstract/Free Full Text]
• Wada H, Kobayashi Y, Yasu T, et al: Multidetector computed tomography for imaging of subendocardial infarction: Prediction of wall motion recovery after reperfused anterior myocardial infarction. Circ J 68:512-514, 2004.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Saito K, Saito M, Komatu S, et al: Real-time four-dimensional imaging of the heart with multidetector row CT. Radiographics 23:e8-e8, 2003.[Abstract/Free Full Text]
• Juergens KU, Grude M, Fallenberg EM, et al: Using ECG-gated multidetector CT to evaluate global left ventricular myocardial function in patients with coronary artery disease. Am J Roentgenol 179:1545-1550, 2002.[Abstract/Free Full Text]
• Wintersperger BJ, Nikolaou K, Jakobs TF, et al: Cardiac multidetector-row computed tomography: Initial experience using 16 detector-row systems. Crit Rev Comput Tomogr 44:27-45, 2003.[CrossRef][Medline] [Order article via Infotrieve]
• Ropers D, Baum U, Pohle K, et al: Detection of coronary artery stenoses with thin-slice multidetector row spiral computed tomography and multiplanar reconstruction. Circulation 107:664-666, 2003.[Abstract/Free Full Text]

Angiology, Vol. 57, No. 2, 155-160 (2006)
DOI: 10.1177/000331970605700204


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Web of Science (1) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sakakura, K. Articles by Saito, M. Search for Related Content PubMed PubMed Citation Articles by Sakakura, K. Articles by Saito, M. Pubmed/NCBI databases Medline Plus Health Information CT Scans Heart Attack Social Bookmarking                         What's this?