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Low-dose Fixed Combination of Bisoprolol/Hydrochlorothiazide as First Line for Hypertension: A Review of the Rationale and Clinical Evidence

Hypertension and Cardiovascular Research Clinic, Georgetown University/Veterans Affairs Medical Center, Washington, D.C., jimpapdoc{at}yahoo.com

Vassilios Papademetriou, MD, FACC

Hypertension and Cardiovascular Research Clinic, Georgetown University/Veterans Affairs Medical Center, Washington, D.C.

Essential hypertension is a heterogeneous multifactorial disease. Data from the National Health and Nutritional Examination Survey and from the World Health Organization have clearly demonstrated that, worldwide, less than 30% of hypertensive patients are adequately controlled by our currently accepted blood pressure goals. Although monotherapy is often unable to achieve blood pressure goals, the use of fixed low-dose combination drugs as alternative treatment seems to be related to a better antihypertensive efficacy and higher response rates in the low range of doses as the result of complementary mechanisms of antihypertensive effects. Indeed clinical trials have shown that initial low-dose combination therapy is superior as compared with treatment by the stepped-care and the sequential monotherapy approach, while recently, low-dose combination therapy for initial antihypertensive therapy instead of the stepped-care approach or of sequential monotherapy has been recommended. This review summarizes the beneficial effect of low-dose bisoprolol/ hydrochlorothiazide combination in the treatment of patients with stage I and II hypertension.

Key Words: bisoprolol/HCTZ • combination • hypertension

This version was published on October 1, 2009

Angiology, Vol. 60, No. 5, 601-607 (2009)
DOI: 10.1177/0003319708324926


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