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Is Polymorphism Within eNOS Gene Associated With the Late Onset of Myocardial Infarction? A Pilot Study

Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Poland, aniagluba{at}yahoo.pl

Maciej Banach, MD, PhD, FASA, FESC

Department of Hypertension, Medical University of Lodz, Poland

Jacek Rysz, MD, PhD, FASA, FASN

Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Poland

Grzegorz Piotrowski, MD, PhD

Department of Cardiology, M. Kopernik Provincial Specialist Hospital, Lodz, Poland

Wojciech Fendler, MD, PhD

Department of Paediatrics, Medical University of Lodz, Poland

Tadeusz Pietrucha, MD, PhD

Medical Biotechnology, University of Lodz, Poland

Introduction: Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a potent vasodilator. Several polymorphisms in the eNOS gene have been described, some of them being linked with the increased risk of cardiovascular disease, coronary heart disease (CHD), and coronary spasm. Methods and Results: We studied 3 polymorphisms within the gene of eNOS (-786T/C, G10T, and 894 G/T) in patients with their first myocardial infarction (MI) younger than 45 years and in healthy volunteers. We found the relation between the occurrence of eNOS 894G allele and the Gensini score, which describes the severity of CHD (P = .020). Conclusions: The fact that first clinical manifestation of MI occurred in G carriers when the atherosclerotic plaque was much more advanced than in T carriers may suggest that wild-type genotype provided a better compensatory mechanisms due to NO synthesis and/or release. The polymorphisms within eNOS gene G10T, 894G/T, and -786T/C were not associated with the increased risk of MI.

Key Words: eNOS • Gensini score • myocardial infarction • polymorphisms

This version was published on October 1, 2009

Angiology, Vol. 60, No. 5, 588-595 (2009)
DOI: 10.1177/0003319709335031


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