This Article Full Text (PDF) All Versions of this Article: 0003319709335027v1 60/5/576    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Scopus Google Scholar Articles by Badger, S. A. Articles by Hughes, A. E. PubMed PubMed Citation Articles by Badger, S. A. Articles by Hughes, A. E. Social Bookmarking                         What's this?

The Influence of COX-2 Single Nucleotide Polymorphisms on Abdominal Aortic Aneurysm Development and the Associated Inflammation

Vascular and Endovascular Surgery Department, Belfast City Hospital, Northern Ireland, Stephen{at}Badger.tc

Chee V. Soong, MD, FRCS

Vascular and Endovascular Surgery Department, Belfast City Hospital, Northern Ireland

Ian S. Young, MD, FRCP

Centre of Public Health, Queens University Belfast, Northern Ireland

Ann McGinty, PhD

Centre of Public Health, Queens University Belfast, Northern Ireland

Caroline Mercer, PhD

Centre of Public Health, Queens University Belfast, Northern Ireland

Anneq E. Hughes, PhD

Department of Medical Genetics, Queens University Belfast, Northern Ireland

Introduction: Cyclooxygenase (COX)-2 influences cardiovascular disease and serum concentration of high-sensitivity C-reactive protein (hsCRP). The study purpose was to determine the influence of single nucleotide polymorphisms (SNPs) of the COX-2 gene on abdominal aortic aneurysm (AAA) development and serum hsCRP concentrations. Patients and Methods: Patients with AAA and disease-free controls were recruited. High-sensitivity C-reactive protein was measured by an enzyme-linked immunosorbent assay (ELISA) test. The distributions of COX-2 SNPs were investigated (rs20417 and rs4648307). The influence of the COX-2 SNPs on the hsCRP serum concentration was assessed.Results: A total of 230 patients with AAA and 279 controls were included. No difference was found in the genotype distribution of the COX-2 SNPs rs20417 (P = .26) and rs4648307 (P = .90). They did not influence the hsCRP concentration (P = .24 and P = .61, respectively). Haplotype analysis of COX-2 SNPs revealed no difference. Conclusion: These COX-2 SNPs do not play any role in AAA development and do not influence serum hsCRP. These results differentiate AAA development from atherosclerotic diseases.

Key Words: abdominal aortic aneurysm • COX-2 • C-reactive protein • genetic polymorphism

This version was published on October 1, 2009

Angiology, Vol. 60, No. 5, 576-581 (2009)
DOI: 10.1177/0003319709335027


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?