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Gender-specific Effects of Calcitonin Gene-related Peptide and Substance P on Coronary Blood Flow in an Experimental Model

Bioengineering Department, Zhengzhou University, Zhengzhou, Henan, China, hongbao{at}gmail.com, Brookdale University Hospital and Medical Center, Brooklyn, New York

Yang Yan, BS

Brookdale University Hospital and Medical Center, Brooklyn, New York

Cherng Shen, PhD

Department of Electrical Engineering, Chengshiu University, Niaosong, Taiwan, China

Background: Calcitonin gene-related peptide (CGRP) and substance P (SP) play counter-regulatory roles in coronary flow. This study is to assess whether effects of CGRP and SP are gender-specific. Methods: Langendorff-perfused hearts were used to compare coronary flow rates among 119 wild-type, -CGRP and SP receptor knockout mice under various perfusion pressures (20, 30, 40, 50 mmHg). Results: For mouse heart coronary flow rate, deletion of -CGRP gene resulted in significant reduction for both genders at all pressures; female CGRP knockout showed 15.3% reduction (P < .01); male CGRP knockout showed 13.8% reduction (P < .01); no significant difference between male and female CGRP knockout; female SP receptor knockout showed 13.9% increase (P < .01); female SP receptor knockout had a greater percentage decrease than male (P < .01). Conclusions: CGRP plays similar roles as a vasodilator in males and females. SP seems to act as a vasoconstrictor in females.

Key Words: calcitonin gene-related peptide (CGRP) • substance P (SP) • flow rate • heart • gender • coronary

This version was published on October 1, 2009

Angiology, Vol. 60, No. 5, 569-575 (2009)
DOI: 10.1177/0003319708325450


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