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Relationship Between Peripheral Arterial Disease and Metabolic Syndrome

Institute for Hygiene and Medical Ecology, School of Medicine, Belgrade, Serbia, milosmaksimovic71{at}gmail.com

Hristina Vlajinac, MD, PhD

Institute of Epidemiology, School of Medicine, Belgrade, Serbia

Djordje Radak, MD, PhD

Department of Vascular Surgery, Dedinje Cardiovascular Institute, School of Medicine, Belgrade, Serbia

Jelena Marinkovic, PhD

Institute of Medical Statistics and Informatics, School of Medicine, Belgrade, Serbia

Jagoda Jorga, MD, PhD

Institute for Hygiene and Medical Ecology, School of Medicine, Belgrade, Serbia

The aim of the study was to estimate the prevalence of metabolic syndrome among 388 patients with peripheral arterial disease, to determine the relationship between the number of metabolic syndrome components (metabolic syndrome score) and the degree of established and some of the emerging vascular risk factors, and to estimate whether there was any relationship of metabolic syndrome score and other vascular risk factors with the severity of peripheral arterial disease clinical manifestations. Metabolic syndrome was present in 59.8% of the patients with peripheral arterial disease. All metabolic syndrome components were significantly related to metabolic syndrome score. The same was true for the body weight, body mass index, percentage of body fat, total cholesterol/high-density lipoprotein cholesterol ratio, uric acid, and percentage of patients with high-sensitivity C-reactive protein. The metabolic syndrome score was also significantly, but inversely, related to high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and smoking. The degree of peripheral arterial disease clinical manifestations was not related to metabolic syndrome score, but gangrene was significantly positively associated with increased fasting glucose, high-sensitivity C-reactive protein, and lower education.

Key Words: peripheral arterial disease • metabolic syndrome • cross-sectional study

This version was published on October 1, 2009

Angiology, Vol. 60, No. 5, 546-553 (2009)
DOI: 10.1177/0003319708325445


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