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Lipid Profile, Low-Density Lipoprotein Oxidation and Ceruloplasmin in the Progeny of Families With a Positive History of Cardiovascular Diseases and/or Hyperlipidemia

Department of Biological Chemistry, Medical School, kali{at}med.auth.gr

Dimitri P. Mikhailidis, MD, FCP, FRCP, FRCPath

Department of Clinical Biochemistry, Royal Free Hospital campus, University College Medical School, University College London, London, UK

Areti Makedou, MD, PhD

Lipids Research Laboratory, Coronary Artery Disease Prevention Unit, 2nd Pediatric Department, AHEPA University Hospital Aristotle University of Thessaloniki, Thessaloniki, Greece

Stavros Iliadis, Biochemist, PhD

Lipids Research Laboratory, Coronary Artery Disease Prevention Unit, 2nd Pediatric Department, AHEPA University Hospital Aristotle University of Thessaloniki, Thessaloniki, Greece

Anargyros Kourtis, MD, PhD

Lipids Research Laboratory, Coronary Artery Disease Prevention Unit, 2nd Pediatric Department, AHEPA University Hospital Aristotle University of Thessaloniki, Thessaloniki, Greece

Norma Vavatsi-Christaki, MD, PhD

Department of Biological Chemistry, Medical School

Georgios E. Papageorgiou, PhD

Lipids Research Laboratory, Coronary Artery Disease Prevention Unit, 2nd Pediatric Department, AHEPA University Hospital Aristotle University of Thessaloniki, Thessaloniki, Greece

Fifty-eight healthy progeny (mean age ± SD 13.9 ± 7.9 years) of 39 families with a positive history for Cardiovascular Diseases ([CVD] n = 44) or hyperlipidemia (n = 14) were included in the study and were compared with 30 age-matched control participants, with a negative family history, to evaluate lipid profile, ceruloplasmin (Cp), and lipid peroxidation product (malondialdehyde [MDA]) levels, as well as in vitro copper-induced Low-density lipoprotein (LDL) oxidizability. Mean serum levels of total cholesterol, LDL cholesterol (LDL-C), apolipoprotein B-100, and MDA of the participants were significantly higher than those of the controls. Lag time, an LDL resistance oxidation marker, was lower in the study group and negatively correlated with LDL-C (r = -.437, P < .05) and Cp (r = -.272, P < .05) serum levels. In conclusion, progeny with a positive family history for CVD or hyperlipidemia have an atherogenic lipid profile and increased LDL susceptibility to oxidation. High Cp levels seem to be related to lower resistance of LDL to oxidation.

Key Words: LDL oxidation • ceruloplasmin • family history • cardiovascular diseases • children

This version was published on August 1, 2009

Angiology, Vol. 60, No. 4, 455-461 (2009)
DOI: 10.1177/0003319709338174


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