SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Angiology
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0003319708321103v1
0003319708321103v2
60/4/427    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Liu, F.
Right arrow Articles by Huang, Y.-N.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, F.
Right arrow Articles by Huang, Y.-N.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Serial Changes of Circulating Platelet Activation Markers After Carotid Artery Stenting

Fang Liu, MD

Department of Neurology, First Hospital of Peking University, Department of Neurology, Beijing Hospital Ministry of Health

Jin Li, MD

Department of Neurology, Beijing Hospital Ministry of Health

Da-Ming Wang, MD

Department of Neurosurgery, Beijing Hospital Ministry of Health Beijing, China

Jia-Chun Liu, MD

Department of Neurosurgery, Beijing Hospital Ministry of Health Beijing, China

Yi-Ning Huang, MD

Department of Neurology, First Hospital of Peking University, huangyncn{at}yahoo.com

We investigated serial changes of circulation platelet activation markers in 40 patients undergoing carotid artery stenting under the protection of dual antiplatelet therapy and filter devices. Monocyte-platelet aggregates and PAC-1 (a marker specific for activated glycoprotein IIb/IIIa) analyzed by flow cytometry were determined in patients with symptomatic stenosis undergoing elective carotid artery stenting. Blood samples were obtained immediately before stent implantation and 0.5 hours, 18 hours, and 6 days after the procedure, respectively. All patients were already on dual antiplatelet therapy of aspirin and clopidogrel before carotid artery stenting, and all were stented with embolic protection devices. Both circulation monocyte-platelet aggregates and PAC-1 did not change significantly at the various time points after the procedure. Serial changes of monocyte-platelet aggregates and PAC-1 analyzed by flow cytometry fail to indicate the occurrence of platelet activation after carotid artery stenting under the treatment with dual antiplatelet therapy before carotid artery stenting and the application of embolic protection devices during the procedure.

Key Words: carotid arteries • stents • platelet activation

This version was published on August 1, 2009

Angiology, Vol. 60, No. 4, 427-430 (2009)
DOI: 10.1177/0003319708321103
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement