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Role of Pro-/Anti-Inflammatory Cytokines and Their Correlation With Established Risk Factors in South Indians With Coronary Artery Disease

Department of Ocular Biochemistry, Dr. R.P. Centre for Ophthalmic Sciences, India Institute of Medical Sciences, New Delhi

S.K. Sen, MD

Department of Biochemistry, JIP-MER, Pondicherry, India Institute of Medical Sciences, New Delhi, Indi

Alpana Sharma, PhD

Department of Biochemistry, India Institute of Medical Sciences, New Delhi, India, dralpanasharma@ gmail.com

Cytokines are responsible for the modulation of immunological and inflammatory processes and play a significant role in the pathogenesis of coronary artery disease. We estimated the levels of pro-/anti-inflammatory cytokines in South Indian patients with coronary artery disease. The study population comprised of groups 1-3: 100 patients each with acute myocardial infarction, unstable angina, and stable angina, respectively, and group 4 (100 healthy controls). Cytokine levels (interleukin-6, interleukin-8, interleukin-10, and tumor necrosis factor-) were estimated by enzyme-linked immunosorbent assay (ELISA). Interleukin-6, interleukin-8, and tumor necrosis factor- levels were significantly higher in patients from groups 1 and 2, than in group 3 and controls. Acute myocardial infarction patients exhibited higher serum levels of interleukin-10 compared with other groups and control subjects. Patients with unstable angina had significantly lower interleukin-10 concentrations than those with stable angina. The ratios of pro-/anti-inflammatory cytokines in all the study groups increased significantly when patients with unstable angina were compared to other groups. In patients with acute myocardial infarction, interleukin-10 and tumor necrosis factor- levels showed significant correlation with established risk factors such as body mass index, blood pressure, and lipid levels. Acute myocardial infarction patients show elevation in proinflammatory and anti-inflammatory cytokines, while unstable angina is associated with low levels of serum interleukin-10. Higher levels of anti-inflammatory cytokine interleukin-10 may be needed to provide protection in unstable angina. These cytokines are markers of coronary artery disease and may be used for the identification of high-risk patients with unstable angina/acute myocardial infarction.

Key Words: coronary artery disease • acute coronary syndromes • acute myocardial infarction • unstable angina • stable angina • pro-/anti-inflammatory cytokines • interleukin-6 • interleukin-8 • tumor necrosis factor-alpha • interleukin-10

This version was published on August 1, 2009

Angiology, Vol. 60, No. 4, 419-426 (2009)
DOI: 10.1177/0003319708321101


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