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Effects of Atorvastatin on Vascular Intimal Hyperplasia: An Experimental Rodent Model

Department of Cardiovascular Surgery, Bezm-I Alem Vakif Gureba Hospital, Istanbul, Turkey

Murat Ugurlucan, MD

Department of Cardiovascular Surgery, Medical Faculty, Istanbul University, Istanbul, Turkey, muratugurlucan{at}yahoo.com

Funda Gungor, MD

Obstetrics and Gynecology Clinic, State Hospital of Balikesir, Balikesir, Turkey

Sedat Ziyade, MD

Department of Cardiovascular Surgery, Bezm-I Alem Vakif Gureba Hospital, Istanbul, Turkey

Bekir Inan, MD

Department of Cardiovascular Surgery, Bezm-I Alem Vakif Gureba Hospital, Istanbul, Turkey

Maciej Banach, MD

Department of Cardiology, 1st Chair of Cardiology and Cardiac Surgery, Medical University of Lodz, Poland

Yusuf Kalko, MD

Department of Cardiovascular Surgery, Bezm-I Alem Vakif Gureba Hospital, Istanbul, Turkey

Tahsin Yasar, MD

Department of Cardiovascular Surgery, Bezm-I Alem Vakif Gureba Hospital, Istanbul, Turkey

Introduction Vascular intimal hyperplasia is associated with increased mortality and morbidity. The authors investigated the effects of atorvastatin on vascular intimal hyperplasia. Materials and methods Rats were divided into 4 groups. Groups 1, 2, and 3 had experimental aortic injury and received intraperitoneal injection of atorvastatin, solvent, or 0.9% NaCl, respectively. Group 4 was a nonintervention (laparotomy only) control group. Animals were sacrificed after 3 weeks. Blood samples and injured aortic segment were analyzed. Results Atorvastatin administration significantly lowered total and low-density lipoprotein cholesterol levels (P = .012 and P = .001, respectively), intima—media ratio (P = .002), and intimal smooth muscle cell accumulation (P < .05) in group 1. Luminal narrowing in animals in group 1 was significantly lower than that in animals in groups 2 and 3, but was higher than in animals in group 4 (P = .009). Conclusions Atorvastatin suppresses intimal hyerplasia and aids in intimal regeneration by lowering blood lipids and intimal smooth muscle cell accumulation.

Key Words: aorta • intimal hyperplasia • statin

This version was published on June 1, 2009

Angiology, Vol. 60, No. 3, 370-377 (2009)
DOI: 10.1177/0003319708321102


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