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Ankle-Brachial Index and Extent of Atherosclerosis in Patients From the Middle East (the AGATHA-ME Study): A Cross-Sectional Multicenter Study

Department of Cardiology and Cardiovascular Surgery, Hamad Medical Corporation, Qatar

Haitham Amin, FRCP, FSCAI

Department of Cardiology, Bahrain Defence Hospital, Bahrain

Ibrahim Rashdan, MD, FRCPC, FACC

Cardiology/Chest Hospital, Kuwait

Kadhim Souliman, FESC, FRCP (Glasg), FRCPI

Department of Cardiology, Royal Hospital, Oman

Dirk Deleu, MD

Department of Neurology, Hamad Medical Corporation, Qatar

Kamran Saadat, MD

Department of Neurology, Hamad Medical Corporation, Qatar

Wael Al Mahmeed, MD, FRCPC, ABIM

Department of Cardiology, Sheikh Khalifa Medical Center

Sharif Bakir, MD, FACC, FRCP

Department of Cardiology, Sheikh Khalifa Medical Center

Adel Wasif, MD

Department of Cardiology, Alsief Hospital

Azan Ben Brek, MD, FACC

Department of Cardiology, Rashid Hospital

Nooshin Bazargani, MD

Department of Cardiology, Dubai Hospital

Ahmed Abdel Aziz, MD

Department of Neurology, Alsief Hospital

Rajvir Singh, PhD

Iman Hatou, MD

Department of Cardiology, Dubai Hospital

Hisham Mahmoud, HA

Medical Department in Sanofi-Aventis Gulf Office, United Arab Emirates

Jassim Al Suwaidi, FACC, FSCI, FGHA

Department of Cardiology and Cardiovascular Surgery, Hamad Medical Corporation, Qatar, Jha01{at}hmc.org.qa

To assess the extent of atherothrombosis and the use of the ankle-brachial index (ABI) in populations from the Middle East, we conducted a multicenter study similar to AGATHA (a Global Atherothrombosis Assessment), AGATHA-ME, which included 1341 patients from 18 centers from 5 countries (United Arab Emirates, Kuwait, Qatar, Bahrain, and Oman). Patients were assigned to 2 groups: the with-disease and at-risk groups. Abnormal ABI (0.9) was seen in 31.5% of at-risk patients and 28.2% of with-disease patients. Patients with peripheral arterial disease had the highest frequency of abnormal ABI (77.6%), with 97.8 negative predictive value. The AGATHA-ME study confirms that atherothrombosis disease often occurs at more than 1 site. The ABI is related to the risk factor profile and to the site and extent of atherothrombosis. Gender and diabetes mellitus are associated with the worst parameters.

Key Words: AGATHA • atherosclerosis • ankle-brachial index • peripheral arterial disease • coronary artery disease

This version was published on June 1, 2009

Angiology, Vol. 60, No. 3, 329-334 (2009)
DOI: 10.1177/0003319708321585


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