This Article Full Text (PDF) All Versions of this Article: 0003319708330008v1 0003319708330008v2 60/3/322    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kaminski, K. A. Articles by Musial, W. J. Search for Related Content PubMed PubMed Citation Articles by Kaminski, K. A. Articles by Musial, W. J. Social Bookmarking                         What's this?

Percutaneous Coronary Interventions Affect Concentrations of Interleukin 6 and Its Soluble Receptors in Coronary Sinus Blood in Patients With Stable Angina

Karol A. Kamiski, MD, PhD

Medical University of Bialystok, Department of Cardiology, Bialystok, Poland, fizklin{at}wp.pl

Anna Kozieradzka, MD

Medical University of Bialystok, Department of Cardiology, Bialystok, Poland

Tomasz Bonda, MD

Medical University of Bialystok, Department of Cardiology, Bialystok, Poland

Maciej Banach, MD, PhD

University of Lodz, Department of Nephrology, Hypertension and Family Medicine, Poland

Marcin Kozuch, MD

Medical University of Bialystok, Department of Invasive Cardiology, Bialystok, Poland

Izabela Wojtkowska, MD, PhD

National Institute of Cardiology, Intensive Cardiac Care Unit, Warsaw, Poland

Sawomir Dobrzycki, MD, PhD

Medical University of Bialystok, Department of Invasive Cardiology, Bialystok, Poland

Pawe Kralisz, MD

Medical University of Bialystok, Department of Invasive Cardiology, Bialystok, Poland

Konrad Nowak, MD

Medical University of Bialystok, Department of Invasive Cardiology, Bialystok, Poland

Przemysaw Prokopczuk, MD, PhD

Medical University of Bialystok, Department of Invasive Cardiology, Bialystok, Poland

Dimitri P. Mikhailidis, MD, FRCP

Department of Clinical Biochemistry, Royal Free Hospital Campus, University College Medical School, University College London, London

Wlodzimierz J. Musial, MD, PhD

Medical University of Bialystok, Department of Cardiology, Bialystok, Poland

Coronary stenting may create local inflammatory reaction. Interleukin 6 effects depend on the presence of soluble receptors (sIL-6R and sgp130) that facilitate or impede interleukin 6 signal transduction. Concentrations of interleukin 6 and its soluble receptors were assessed in aorta and coronary sinus after stenting in optimally treated stable angina patients scheduled for elective stenting. Baseline levels of interleukin 6 and its soluble receptors in patients did not differ from healthy controls. Initial levels of sIL-6R in aorta were significantly higher than in coronary sinus but this difference disappeared after intervention. Stenting caused interleukin 6 concentration increase to a similar extent both in coronary sinus and in aorta. Moreover, there was significantly higher sgp130 concentration in coronary sinus than in aorta. Coronary intervention increases concentration of interleukin 6 in patients with stable angina. It affects the cardiac level of interleukin 6 soluble receptors what may influence the local inflammatory reaction.

Key Words: coronary stenting • interleukin 6 • inflammation • ischemic heart disease

This version was published on June 1, 2009

Angiology, Vol. 60, No. 3, 322-328 (2009)
DOI: 10.1177/0003319708330008


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?