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The Effect of Negative Pressure Therapy on the Femoral Vein Blood Flow and Wall Structure

Department of Vascular Surgery, Red Cross Hospital of Athens, christoslioupis{at}yahoo.gr

Thomas Kotsis, MD

Department of Vascular Surgery, Red Cross Hospital of Athens

Calypso Barbatis, MD

and Department of Histopathology, Red Cross Hospital of Athens

Eleni Seretis, MD

Department of Electron Microscopy, Saint Savas Anticancer Hospital

Alexandros Nomikos, MD

and Department of Histopathology, Red Cross Hospital of Athens

Irene Volondakis-Baltatzis, MD

Department of Electron Microscopy, Saint Savas Anticancer Hospital

Apostolos Papalois, BSc

Experimental-Research Center Elpen Pharmaceuticals Athens, Greece

Vasilios Andrikopoulos, MD

Department of Vascular Surgery, Red Cross Hospital of Athens

David Leaper, MD, ChM

Wound Healing Research Unit, Cardiff University, Cardiff, Wales

Negative pressure therapy has been recently used for managing lymphatic or infective groin complications. The aim of this study was to investigate any possible association between application of negative pressure therapy in the groin area and deep-vein thrombosis. Acute surgical wounds were created at the inguinal areas in 7 pigs. Different negative pressures ranging from –50 to –200 mmHg were applied directly over the femoral vessels, and blood flow alterations were studied using a Doppler ultrasound. Femoral vein specimens were also removed for histological examination after 12 hours of therapy. It has been demonstrated that negative pressure therapy does not significantly alter the baseline lower limb venous return. Histology demonstrated several changes, which are associated with vein thrombogenesis. The hemodynamic and pathological findings still leave a potential for thrombogenic effects of negative pressure therapy and warrant care to protect the femoral veins, with the use of thrombosis prophylaxis measures.

Key Words: negatine pressure therapy • VAC therapy • vacuum-assisted closure • deep-vein thrombosis • femoral veins • pigs • hemodynamic effects • thrombogenicity

This version was published on June 1, 2009

Angiology, Vol. 60, No. 3, 290-300 (2009)
DOI: 10.1177/0003319708318376


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