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Plasma Total Antioxidant Activity in Comparison With Plasma NO and VEGF Levels in Patients With Metabolic Syndrome

Department of Molecular Cardionephrology and Hypertension, Medical University of Lodz, Lodz, Poland, maciejbanach{at}aol.co.uk, Department of Internal Diseases and Cardiological Rehabilitation, Medical University of Lodz, Lodz, Poland

Edward Kowalczyk, MD, PhD

Department of Pharmacology, Medical University of Lodz, Lodz, Poland

Maciej Banach, MD, FESC, FASA, FSGC

Department of Pharmacology, Medical University of Lodz, Lodz, Poland

Julita Ciecwierz, MD, PhD

Department of Pharmacology, Medical University of Lodz, Lodz, Poland

Lucjan Pawlicki, MD, PhD

Department of Internal Diseases and Cardiological Rehabilitation, Medical University of Lodz, Lodz, Poland

Jan Kowalski, MD, PhD

Department of Internal Diseases and Cardiological Rehabilitation, Medical University of Lodz, Lodz, Poland

Introduction: The aim of our study was to estimate plasma antioxidant activity as well as plasma nitric oxide (NO) and vascular endothelial growth factor levels in patients with metabolic syndrome compared with healthy participants.

Material and Methods: Fifty patients (24 women and 26 men, mean age 55.9 + 11.8 years) with metabolic syndrome were compared with 25 healthy participants (12 women and 13 men, mean age 54.2 + 12.8 years). Plasma total antioxidant activity and plasma levels of NO and VEGF were determined in all participants.

Results: In the patients with metabolic syndrome, plasma total antioxidant activity, nitric oxide, and vascular endothelial growth factor were significantly lower (P < .001) than that observed in healthy participants (3.2 + 1.6 vs 6.4 + 2.1 mM/L), (6.3 + 2.2 vs 9.8 + 2.7 µM/L), and 71.0 + 16.9 vs 137.5 + 12.6 pg/mL), respectively.

Conclusions: Decreased plasma total antioxidant activity, NO, and VEGF levels in patients with metabolic syndrome reflect significant endothelial dysfunction. This suggests that oxidation—reduction balance disorders might play an important role in this process

Key Words: metabolic syndrome • plasma total antioxidant activity • nitric oxide • vascular endothelial growth factor

This version was published on February 1, 2009

Angiology, Vol. 60, No. 1, 87-92 (2009)
DOI: 10.1177/0003319708327165


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