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Ceruloplasmin is a Better Predictor of the Long-Term Prognosis Compared With Fibrinogen, CRP, and IL-6 in Patients With Severe Unstable Angina

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece, aziakas{at}med.auth.gr

Stavros Gavrilidis, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

Efthimia Souliou, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

George Giannoglou, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

Ioannis Stiliadis, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

Haralambos Karvounis, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

George Efthimiadis, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

Sotirios Mochlas, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

M. Arvanitidou Vayona, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

Apostolos Hatzitolios, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

Christos Savopoulos, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

Ifigenia Pidonia, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

George Parharidis, MD

1st Cardiology Department, AHEPA, University Hospital, Thessaloniki, Greece

Background. We investigated the time course and prognostic value of fibrinogen (Fib), C-reactive protein (CRP), interleukin-6 (IL-6), and ceruloplasmin (CP) in patients with severe unstable angina. Methods. All 4 substances were measured on admission and after 6, 12, 24, 48, and 72 hours, and after 7 days and 6 months in 40 patients with Braunwald's classification class IIIB unstable angina. Results. All recorded substances increased significantly; 15 patients had cardiovascular events during hospitalization and 11 patients during follow-up. The time course and the mean values of Fib, CRP, and IL-6 were similar in patients with and without complications both during hospitalization and follow-up. However, CP levels from 6 hours until 6 months were significantly higher in patients with complications during follow-up (P < .05). Conclusions. Fib, CRP, IL-6, and CP levels alter in patients with severe unstable angina. However, only CP levels were related to 12-month follow-up prognosis.

Key Words: fibrinogen • C-reactive protein • interleukin-6 • ceruloplasmin • severe unstable angina • prognosis

This version was published on February 1, 2009

Angiology, Vol. 60, No. 1, 50-59 (2009)
DOI: 10.1177/0003319708314249


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