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Elevated Osteopontin Levels in Patients With Peripheral Arterial Disease

Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine and Shinshu University Hospital, Nagano, Japan

Kazunori Aizawa, MD, PhD

Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine and Shinshu University Hospital, Nagano, Japan

Hiroki Kasai, MD, PhD

Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine and Shinshu University Hospital, Nagano, Japan

Atsushi Izawa, MD, PhD

Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine and Shinshu University Hospital, Nagano, Japan

Takeshi Tomita, MD, PhD

Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine and Shinshu University Hospital, Nagano, Japan

Setsuo Kumazaki, MD

Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine and Shinshu University Hospital, Nagano, Japan

Hiroshi Tsutsui, MD, PhD

Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine and Shinshu University Hospital, Nagano, Japan

Jun Koyama, MD, PhD

Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine and Shinshu University Hospital, Nagano, Japan

Shigetaka Shimodaira, MD, PhD

Division of Blood Transfusion, Shinshu University Graduate School of Medicine and Shinshu University Hospital, Nagano, Japan

Masafumi Takahashi, MD, PhD

Division of Blood Transfusion, Shinshu University Graduate School of Medicine and Shinshu University Hospital, Nagano, Japan

Uichi Ikeda, MD, PhD

Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine and Shinshu University Hospital, Nagano, Japan, uikeda{at}hsp.md.shinshu-u.ac.jp

This study was carried out to compare concentrations of osteopontin (OPN) and osteoprotegerin (OPG) in peripheral arterial disease (PAD). The study population consisted of 200 consecutive subjects in whom both OPN/OPG and ankle—brachial index were measured. It was found that OPN levels, but not OPG levels, were significantly more increased in patients with PAD than those without PAD. Serum OPN levels were significantly lower in subjects with angiotensin converting enzyme inhibitors or angiotensin II receptor blockers than those without these agents. In this study, it has been demonstrated for the first time that serum OPN levels are related to PAD. Inhibition of renin— angiotensin system could decrease OPN levels and prevent the progression of PAD.

Key Words: cytokine • peripheral arterial disease • osteopontin

This version was published on February 1, 2009

Angiology, Vol. 60, No. 1, 42-45 (2009)
DOI: 10.1177/0003319708314250


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