This Article Full Text (PDF) All Versions of this Article: 0003319708322387v1 60/1/12    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Web of Science (1) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Bo, M. Articles by Fonte, G. Search for Related Content PubMed PubMed Citation Articles by Bo, M. Articles by Fonte, G. Social Bookmarking                         What's this?

High-Sensitivity C-Reactive Protein Is Not Independently Associated With Peripheral Subclinical Atherosclerosis

SCDU Geriatria, Dipartimento di Discipline Medico Chirurgiche, Azienda Sanitaria San Giovanni Battista, Turin, Italy, mario.bo{at}unito.it

Laura Corsinovi, MD

SCDU Geriatria, Dipartimento di Discipline Medico Chirurgiche, Azienda Sanitaria San Giovanni Battista, Turin, Italy

Alessia Brescianini, MD

SCDU Geriatria, Dipartimento di Discipline Medico Chirurgiche, Azienda Sanitaria San Giovanni Battista, Turin, Italy

Alessandro Sona, MD

SCDU Geriatria, Dipartimento di Discipline Medico Chirurgiche, Azienda Sanitaria San Giovanni Battista, Turin, Italy

Marco Astengo, MD

SCDU Geriatria, Dipartimento di Discipline Medico Chirurgiche, Azienda Sanitaria San Giovanni Battista, Turin, Italy

Raluca Dumitrache, MD

SCDU Geriatria, Dipartimento di Discipline Medico Chirurgiche, Azienda Sanitaria San Giovanni Battista, Turin, Italy

Maria Federica Ferrio, MD

SCDU Neuroradiologia, Dipartimento di Diagnostica per Immagini, Azienda Sanitaria San Giovanni Battista, Turin, Italy

Larisa Pricop, MD

SCDU Geriatria, Dipartimento di Discipline Medico Chirurgiche, Azienda Sanitaria San Giovanni Battista, Turin, Italy

Gianfranco Fonte, MD

SCDU Geriatria, Dipartimento di Discipline Medico Chirurgiche, Azienda Sanitaria San Giovanni Battista, Turin, Italy

Objective. This study investigated whether high-sensitivity C-reactive protein (hs-CRP) levels are independently associated with subclinical peripheral atherosclerosis. Methods. Clinical variables, cardiovascular (CV) risk factors, 10-year CV risk, the ankle-brachial Index (ABI), and the carotid intima—media thickness (cIMT) were determined in a sample of consecutive subjects free from previous CV disease, admitted for a first visit at a lipid clinic. Results. In the overall sample (320 subjects, mean age 63 years, 35.8% men), hs-CRP levels were associated with major CV risk factors, 10-year CV risk, lower ABI, and higher cIMT values. In a logistic model, after adjustment for significant covariates, the associations of hs-CRP levels with ABI and cIMT were no longer statistically significant. Conclusions. Among asymptomatic, moderate- to-high CV risk subjects, hs-CRP levels were associated with severity of peripheral atherosclerosis, but these associations were not independent of traditional CV risk factors, suggesting a limited predictive role of hs-CRP for subclinical atherosclerosis.

Key Words: C-reactive protein • intima—media thickness (IMT) • ankle—brachial index (ABI) • cardiovascular risk • peripheral subclinical atherosclerosis

This version was published on February 1, 2009

Angiology, Vol. 60, No. 1, 12-20 (2009)
DOI: 10.1177/0003319708322387


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?