This Article Full Text (PDF) All Versions of this Article: 0003319708318380v1 60/1/115    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Badger, S. A. Articles by Soong, C. V. Search for Related Content PubMed PubMed Citation Articles by Badger, S. A. Articles by Soong, C. V. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Aortic Aneurysm Smoking Social Bookmarking                         What's this?

The Role of Smoking in Abdominal Aortic Aneurysm Development

Department of Vascular and Endovascular Surgery, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom, Stephen{at}Badger.tc

Mark E. O'Donnell, MB, MRCS

Department of Vascular and Endovascular Surgery, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom

Muhammed A. Sharif, FRCS

Department of Vascular and Endovascular Surgery, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom

Cyril McMaster

Department of Pediatrics, Queens University Belfast, Belfast, Northern Ireland, United Kingdom

Ian S. Young, MD, FRCP

Department of Medicine, Queens University Belfast, Belfast, Northern Ireland, United Kingdom

Chee V. Soong, MD, FRCS

Department of Vascular and Endovascular Surgery, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom

Abdominal aortic aneurysm is common. The aim of this study was to assess the effect of smoking on prevalence and management. Patients attending the vascular unit and appropriate controls were prospectively recruited. A smoking history revealed tobacco exposure in pack years. Serum cotinine was assessed biochemically. Independent risk factors were statistically determined. In all, 202 (186 men) patients were recruited, with 202 (197 men) controls. A total of 69 patients tested positive for cotinine, whereas 39 controls were positive (P = .001). Smoking and ischemic heart disease were significant predictors for aneurysm prevalence. Cardiac disease emerged as a more important predictor than smoking in symptomatic patients. In noncardiac patients, smoking and hypercholesterolemia were significant risk factors. Smoking is a significant predictor for aneurysm development. In high-risk patients, the cardiac disease process is the most important factor, with control of this imperative. However, in noncardiac patients, smoking cessation and lipid-lowering therapy are crucial.

Key Words: abdominal aortic aneurysm • smoking • risk factors • cotinine

This version was published on February 1, 2009

Angiology, Vol. 60, No. 1, 115-119 (2009)
DOI: 10.1177/0003319708318380


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?