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Baseline ICAM-1 and VCAM-1 Are Increased in Initially Healthy Middle-Aged Men Who Develop Cardiovascular Disease During 6.6 Years of Follow-Up

Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden, caroline.schmidt{at}wlab.gu.se

Johannes Hulthe, MD, PhD

Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden

Björn Fagerberg, MD, PhD

Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden

The objective of the present study was to investigate if there was a difference in baseline serum concentrations of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) between groups with and without cardiovascular events during a mean follow-up of 6.6 years in a group of initially healthy 58-year-old men. A further aim was to examine if high serum concentrations of ICAM-1 and VCAM-1 were associated with carotid and femoral artery plaque occurrence, separately. Men with cardiovascular events during follow-up had higher median serum ICAM-I and VCAM-I than those without events (P < .05). The median of serum ICAM-I and VCAM-1 in the event group was used as the cutoff level, and in those with ICAM-1 and VCAM-1 above the cutoff value, there was an increased risk of having a plaque in the femoral artery (OR = 2.8, 95% CI = 1.8-4.3; and OR = 1.6, 95% CI = 1.1-2.5, respectively).

Key Words: cellularadhesionmolecules;B-modeultrasound • plaque • carotid artery • femoral artery • cardiovascular event

This version was published on February 1, 2009

Angiology, Vol. 60, No. 1, 108-114 (2009)
DOI: 10.1177/0003319708316899


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