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Angiology
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Flow-Mediated Arterial Dilation in Primary Antiphospholipid Syndrome

Franca Bilora, MD

Clinica Medica , Università di Padova, Padova, Italy, franca.bilora{at}sanita.padova.it

Maria Teresa Sartori, MD

Clinica Medica , Università di Padova, Padova, Italy

Ezio Zanon, MD

Clinica Medica , Università di Padova, Padova, Italy

Enrico Campagnolo, MD

Clinica Medica , Università di Padova, Padova, Italy

Marianna Arzenton, MD

Clinica Medica , Università di Padova, Padova, Italy

Alberto Rossato, MD

Clinica Medica , Università di Padova, Padova, Italy

Objective. To investigate precocious alterations in the artery wall of patients with primary antiphospholipid syndrome (APS). Methods. We evaluated flow-mediated dilation (FMD) of the brachial artery and intima-media thickness (IMT) of carotid arteries in 16 patients and 16 healthy controls matched for age, gender, and other cardiovascular risk factors. Results. FMD of the brachial artery was significantly lower in patients than in controls (6.3 ± 5.2% vs 18.2 ± 2.7; P < .005). IMT was similar in the 2 groups. FMD was significantly reduced in patients with anticardiolipin antibodies IgM. Conclusions. APS correlates closely with precocious atherosclerosis, and the correlation with a type of anticardiolipin antibody may be predictive of more accelerated atherosclerosis.

Key Words: flow-mediated dilation • primary antiphospholipid syndrome • atherosclerosis

This version was published on February 1, 2009

Angiology, Vol. 60, No. 1, 104-107 (2009)
DOI: 10.1177/0003319708315304
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