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Sodium-Lithium Countertransport Activity in Healthy, Dyslipidemic, and Hypertensive Individuals

1st Propedeutic Department of Internal Medicine, AHEPA University Hospital

Apostolos I. Hatzitolios, MD

1st Propedeutic Department of Internal Medicine, AHEPA University Hospital, axatzito{at}med.auth.gr

Niki A. Katsiki, MD

1st Propedeutic Department of Internal Medicine, AHEPA University Hospital

Maria Baltatzi, MD

1st Propedeutic Department of Internal Medicine, AHEPA University Hospital

Maria Kosmidou, MD

1st Propedeutic Department of Internal Medicine, AHEPA University Hospital

Nikolaos Raikos, MD

Laboratory of Forensics and Toxicology, Aristotle University of Thessaloniki, Greece

Dimitri P. Mikhailidis, MD

Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Hospital Campus, University College London (University of London), London, United Kingdom

Antonios G. Ziakas, MD

1st Propedeutic Department of Internal Medicine, AHEPA University Hospital

Georgia Kaiafa, MD, Phd

1st Propedeutic Department of Internal Medicine, AHEPA University Hospital

Niki Tsesmeli, MD

1st Propedeutic Department of Internal Medicine, AHEPA University Hospital

The aim of our study was to investigate the role of dyslipidemia on red blood cell sodium-lithium countertransport activity in healthy and hypertensive individuals. A total of 128 Caucasian individuals, aged 20 to 60 years old, were divided into 4 groups: dyslipidemic/ hypertensive, dyslipidemic/normotensive, normolipidemic/hypertensive, and normolipidemic/ normotensive (controls). Sodiumlithium countertransport activity was determined based on the Canessa et al method. Sodium-lithium countertransport activity was significantly higher in all patient groups compared with controls (P < .001) and similar in the 3 patient groups. Sodium-lithium countertransport activity was significantly and positively associated with triglyceride levels (P < .001), body mass index (P < .001), total cholesterol levels (P = .001), and systolic (P = .001) and diastolic blood pressure (P = .001). In multivariate regression analysis, triglycerides made the largest contribution to sodiumlithium countertransport variation among the variables tested (R² = 0.273). Our results suggest that dyslipidemia affects sodium-lithium countertransport activity independently of essential hypertension and even to a greater extent than hypertension.

Key Words: sodium/lithium countertransport activity • dyslipidemia • hypertension • triglycerides

This version was published on January 1, 2009

Angiology, Vol. 59, No. 6, 727-735 (2009)
DOI: 10.1177/0003319708319784


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