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Association Between Protein-Bound Sialic Acid and High-Sensitivity C-Reactive Protein in Essential Hypertension: A Possible Indication of Underlying Cardiovascular Risk

Department of Biochemistry Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India

Hanumanthappa Nandeesha, MD

Department of Biochemistry Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India

Nambiar Selvaraj, MSc

Department of Biochemistry Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India

Zachariah Bobby, PhD

Department of Biochemistry Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India, zacbobby{at}yahoo.com

Aparna Agrawal, MD

Department of Medicine Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India

Purushothaman Pavithran, MSc

Department of Physiology Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India

The aim of this study was to examine the possible alteration in the levels of C-reactive protein, protein-bound sialic acid, and other lipid risk factors in newly diagnosed essential hypertensive subjects. In all, 56 hypertensive and 33 normotensive male subjects were enrolled in the study. Lipid profile, C-reactive protein, apolipoprotein-B, and protein-bound sialic acid were estimated in both the groups. Total cholesterol, triglyceride, low-density lipoprotein—cholesterol, C-reactive protein, apolipoprotein-B, and protein-bound sialic acid were significantly increased in patients with essential hypertension. Correlation analysis revealed a significant association between the protein-bound sialic acid with mean arterial pressure, C-reactive protein, and low-density lipoprotein—cholesterol. The findings of the present study suggest that in essential hypertension there is an association between protein-bound sialic acid and C-reactive protein, which reflects the clustering of cardiovascular risk factors in these patients.

Key Words: sialic acid • C-reactive protein • essential hypertension • cardiovascular disease • lipid profile

This version was published on January 1, 2009

Angiology, Vol. 59, No. 6, 721-726 (2009)
DOI: 10.1177/0003319708314246


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