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Angiology
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Cell Therapy in Peripheral Arterial Disease

Ibhar Al Mheid, MD

Division of Cardiology, Emory University School of Medicine, Atlanta Georgia

Arshed A. Quyyumi, MD, FACC

Division of Cardiology, Emory University School of Medicine, Atlanta Georgia, aquyyum@ emory.edu

Management of advanced obstructive vascular disease affecting the extremities poses tremendous challenges for physicians and patients. Peripheral arterial disease is often a consequence of obstructive atherosclerosis affecting the ileofemoral circulation but is also rarely a result of nonatherosclerotic conditions such as thromboangiitis obliterans (Buerger's disease). Consequences range from the presence of asymptomatic obstruction to intermittent claudication, development of rest pain, ulceration, gangrene, and amputation. A relatively new and promising approach using cell therapy has recently been developed to treat intractable symptoms related to ischemia in subjects with peripheral arterial disease in whom conventional medical therapy and revascularization modalities have been exhausted.

Key Words: peripheral arterial disease • Buerger's disease • cell therapy • endothelial progenitor cells

This version was published on January 1, 2009

Angiology, Vol. 59, No. 6, 705-716 (2009)
DOI: 10.1177/0003319708321584
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