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The Effects of Different β-Blockers on Left-Ventricular Volume and Function After Primary Coronary Stenting in Acute Myocardial Infarction

Cardiology Division, Yonsei Cardiovascular Center, Yonsei University College of Medicine, shl1106{at}yuhs.ac

Seong-Bo Yoon, MD

Cardiology Division, Yonsei Cardiovascular Center, Yonsei University College of Medicine

Jung-Rae Cho, MD

Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University College of Medicine Seoul, Republic of Korea

Seonghoon Choi, MD

Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University College of Medicine Seoul, Republic of Korea

Jae-Hun Jung, MD

Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University College of Medicine Seoul, Republic of Korea

Namho Lee, MD

Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University College of Medicine Seoul, Republic of Korea

The beneficial effect of β-blockers is reported in myocardial infarction (MI). This study compared the effects of propranolol and carvedilol on left-ventricular (LV) volume and function after acute MI. Serial echocardiographic studies were performed on acute MI patients who were treated with primary coronary stenting and medical treatment, including propranolol or carvedilol. Determinants of the changes in LV volume and function were identified by regression analyses. At 6 months, there was no significant difference in change in the LV end-diastolic volume between patients receiving 2 β-blockers. The increase of LV ejection fraction was greater in patients receiving carvedilol. On multivariate analyses, it was found that the kind of β-blocker had no significant influence on the changes in LV volume or ejection fraction, whereas gender and baseline LV ejection fraction were predictive of change in LV ejection fraction. Compared with propranolol, carvedilol did not have a significant benefit on LV remodeling or function after primary coronary stenting in acute MI.

Key Words: β-adrenergic blockers • carvedilol • ventricular remodeling • ventricular ejection fraction • myocardial infarction

This version was published on January 1, 2009

Angiology, Vol. 59, No. 6, 676-681 (2009)
DOI: 10.1177/0003319708315303


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