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Brachial Artery Flow-Mediated Vasodilation in Patients With Cardiac Syndrome X

Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li City, Taiwan, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Cardiovascular Center, Far Eastern Memorial Hospital, Taipei, Taiwan

Bai-Chin Lee, MD

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

Kuo-Chin Chen, MD

Cardiovascular Center, Far Eastern Memorial Hospital, Taipei, Taiwan

Ching-Sung Weng, PhD

Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li City, Taiwan, las1012.tw@yahoo .com.tw

Shu-Hsun Chu, MD

Cardiovascular Center, Far Eastern Memorial Hospital, Taipei, Taiwan

Cardiac syndrome X (CSX) differs from coronary artery disease (CAD) and is characterized by angina, positive stress test, and patent coronary arteries. The probable mechanism is a microvascular disorder associated with endothelial dysfunction. In this study, brachial artery flow-mediated vasodilation was used as well as the endothelin-1 assay to assess endothelial function in patients with cardiac syndrome X (CSX), coronary artery disease (CAD), and healthy controls. All subjects underwent a 2-step brachial artery flow-related vasodilatation test. Serum endothelin-1, one of the most potent constricting factors, was measured for all participants. Patients with CSX had a lower brachial artery dilation ratio than controls but higher than that of CAD patients. Control subjects and CSX patients had higher endothelin-1 levels than CAD patients. CSX patients were found to have worse endothelial function than healthy volunteers, but patients with CAD had even worse endothelium function than CSX patients.

Key Words: cardiac syndrome X • endothelium • flow-mediated vasodilatation • endothelin-1

This version was published on October 1, 2008

Angiology, Vol. 59, No. 5, 581-586 (2008)
DOI: 10.1177/0003319707308032


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