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In-Stent Stenosis: Potential Role of Increased Oxidative Stress and Glutathione-Linked Detoxification Mechanisms

Division of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana

Pratap C. Reddy, MD

Division of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana

Deepti Shukla, MD

Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana

Gloria C. Caldito, PhD

Department of Biometry, Louisiana State University Health Sciences Center, Shreveport, Louisiana

Lakshminarayan Yerra, MD

Division of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana

Tak Y. Aw, PhD

Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, taw{at}lsuhsc.edu

This study was designed to determine whether red-cell oxidative stress status and antioxidant enzyme levels can serve as markers in patients predisposed to in-stent stenosis. Blood was collected from patient groups undergoing coronary angiography for chest pain evaluation, namely, group A (without coronary artery disease), group B (previous coronary stents without in-stent stenosis), and group C (previous coronary stents with in-stent stenosis). Thiobarbituric acid reactive substances (measure of lipid peroxidation), glutathione-linked detoxification enzymes, catalase, and superoxide dismutase were determined. Compared with group A, patients in group C showed increased lipid peroxidation products and glutathione-S-transferase but decreased glutathione peroxidase and glutathione reductase activities. Results in group B patients were intermediate between those of groups A and C with significant decreases in glutathione peroxidase versus controls. In-stent stenosis is associated with significant increase in lipid peroxidation and attenuated glutathione-linked detoxification enzymes, consistent with oxidative stress.

Key Words: in-stent stenosis • coronary angioplasty • oxidative stress and coronary artery disease • glutathione • glutathione detoxification enzymes • glutathione peroxidase • glutathione reductase

This version was published on August 1, 2008

Angiology, Vol. 59, No. 4, 469-474 (2008)
DOI: 10.1177/0003319707309651


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