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Secondary Prevention of Arterial Disease in Very Elderly People: Results From a Prospective Registry (FRENA)

Servicio de Medicina Interna, Hospital Universitario Reina Sofía, Córdoba

Miguel Camafort, MD

Hospital Comarcal Mora d'Ebre, Tarragona

Gregorio Tiberio, MD

Hospital Virgen del Camino, Pamplona, Navarra

José Antonio Carmona, MD

Hospital Alto Guadalquivir, Andújar, Jaén

Carlos Guijarro, MD

Fundación Hospital de Alcorcón, Madrid

Francisco Martínez-Peñalver, MD

Hospital University Virgen Macarena, Sevilla

Manuel Monreal, PhD

Hospital Universitari Germans Trias i Pujol, Barcelona (MM), Spain, mmonreal.germanstrias{at}gencat.net

FRENA Investigators

There is little information on the effectiveness of secondary prevention interventions in very elderly patients. In this article, the incidence of major cardiovascular events during a 12-month follow-up period in a series of consecutive patients with coronary, cerebrovascular, or peripheral artery disease is analyzed. As of October 2006, 1264 patients had been enrolled. Of these, 324 (26%) were 75 years of age. Their incidence rate of 22 events per 100 patient-years (95% CI, 17-28) was over 2-fold the 7.9 (95% CI, 6.2-10) found in those <75 years of age. Among them, only chronic heart failure and diabetes were independently associated with an increased risk for major events, whereas the use of angiotensin II antagonists was associated with a lower risk. Patients 75 years of age had an over 2-fold higher incidence of major cardiovascular events. The use of angiotensin II antagonists was associated with a lower risk.

Key Words: outcome • peripheral arterial disease • secondary prevention

This version was published on August 1, 2008

Angiology, Vol. 59, No. 4, 427-434 (2008)
DOI: 10.1177/0003319707309299


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