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Augmentation Index and Pulse Wave Velocity as Indicators of Cardiovascular Stiffness

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Japan, nakae{at}belle.shiga-med.ac.jp

Shinro Matsuo, MD

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Japan

Tetsuya Matsumoto, MD

Department of General Medicine, Shiga University of Medical Science, Japan

Kenichi Mitsunami, MD

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Japan

Minoru Horie, MD

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Japan

The authors examine the clinical significance of radial augmentation index (rAI) and brachial-ankle pulse wave velocity (baPWV). In 78 hypertensive patients, rAI correlates inversely with pulse rate (PR; r = –0.57, P < .001), but baPWV does not. A weak correlation between rAI and systolic blood pressure (SBP) is observed (r = 0.28, P < .05). rAI has no significant correlation with diastolic blood pressure (DBP). In contrast, baPWV correlates positively with both SBP (r = 0.54, P < .001) and DBP (r = 0.43, P < .001). In 56 of these patients, baPWV correlates with the diastolic parameters—the mitral E/A ratio (r = —0.35, P < .01), pulmonary vein S/D ratio (r = 0.41, P < .01), and deceleration time (r = 0.28, P < .05)—by echocardiography, but AI.P75 (rAI corrected for PR 75 bpm because of PR dependence) does not. Therefore, for detection of diastolic dysfunction, baPWV may be more sensitive than rAI.

Key Words: augmentation index • pulse wave velocity • diastolic function

This version was published on August 1, 2008

Angiology, Vol. 59, No. 4, 421-426 (2008)
DOI: 10.1177/0003319707306299


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