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Angiology
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*Substance via MeSH
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*Dietary Supplements
*Metabolic Syndrome
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Improvement in Circulation and in Cardiovascular Risk Factors With a Proprietary Isotonic Bioflavonoid Formula OPC-3®

Maria R. Cesarone, MD

Department of Biomedical Science, G D'Annunzio University Chieti, Pescara, Italy

Andrea Di Renzo

Department of Biomedical Science, G D'Annunzio University Chieti, Pescara, Italy

Silvia Errichi, MD

Frank Schönlau, PhD

Horphag Research UK, London, United Kingdom

James L. Wilmer, PhD

nutraMetrix®, Division of Market America, Greensboro, North Carolina

Julian Blumenfeld, MD

nutraMetrix®, Division of Market America, Greensboro, North Carolina, nutrametrix{at}nutrametrix.com

This study investigated the efficacy of isotonic bioflavonoid supplementation, OPC-3 on 61 individuals presenting with risk factors meeting the criteria for metabolic syndrome. Subjects were supplemented with a proprietary isotonic bioflavonoid OPC-3 or placebo over 2 months. Plasma oxidative stress status was significantly lowered by 10.1% with OPC-3. All major cardiovascular risk factors were improved with blood pressure, total cholesterol, and fasting blood glucose lowered. OPC-3 significantly improved endothelial function as evaluated by increased vasorelaxation in reactive hyperemia and enhanced diastolic carotid artery flow. Cardiac ultrasound scanning revealed a significant increase of left ventricular ejection fraction. Skin microcirculation was enhanced, and better tissue perfusion led to significantly increased transcutaneous oxygen partial pressure and decreased pCO2. With OPC-3 a dramatic and significant plasma C-reactive protein decrease by 52.1% occurred. Individuals may improve key cardiovascular risk factors by daily supplementation with the bioflavonoid OPC-3 as an important part of a healthier lifestyle.

Key Words: bioflavonoid • OPC-3 • metabolic syndrome • isotonic • cardiovascular risk factors • Pycnogenol

This version was published on August 1, 2008

Angiology, Vol. 59, No. 4, 408-414 (2008)
DOI: 10.1177/0003319708321801
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