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Risk Stratification of Apolipoprotein B, Apolipoprotein A1, and Apolipoprotein B/AI Ratio on the Prevalence of the Metabolic Syndrome: the ATTICA Study

First Cardiology Clinic, School of Medicine, University of Athens, Greece

Demosthenes B. Panagiotakos

Office of Biostatistics - Epidemiology, Department of Dietetics Science-Nutrition, Harokopio University, Athens, Greece, d.b.panagiotakos{at}usa.net

John Skoumas

First Cardiology Clinic, School of Medicine, University of Athens, Greece

Labros Papadimitriou

First Cardiology Clinic, School of Medicine, University of Athens, Greece

Christodoulos Stefanadis

First Cardiology Clinic, School of Medicine, University of Athens, Greece

We investigated the association of apolipoproteins AI and B in relation to the prevalence of metabolic syndrome in a random sample of cardiovascular disease— free adults from the ATTICA study (1,514 men, aged 18-87 y; 1,528 women, aged 18-89 y). Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. The prevalence of metabolic syndrome was 25% in men and 15% in women (P < .001). Using the area under the Receiver Operation Characteristic curve, apolipoprotein B/AI was the best diagnostic marker of metabolic syndrome, the optimal discriminating cut-off value of this ratio was 0.72 (sensitivity 74%, specificity 67%), and individuals with apolipoprotein B/AI ratio greater than 0.74 had 3.29 times higher odds of having metabolic syndrome (95% confidence interval: 2.56-4.21) after adjusting for potential confounders.

Key Words: blood lipids • apolipoprotein • metabolic syndrome • atherosclerosis

This version was published on July 1, 2008

Angiology, Vol. 59, No. 3, 335-341 (2008)
DOI: 10.1177/0003319707307273


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