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This version was published on July 1, 2008
Angiology, Vol. 59, No. 3, 269-277 (2008)
DOI: 10.1177/0003319707306963

Effects of Policosanol (10 mg/d) Versus Aspirin (100 mg/d) in Patients With Intermittent Claudication: A 10-Week, Randomized, Comparative Study

José Illnait, PhD

Medical Surgical Research Centre, Havana City, Cuba, clinica{at}enet.cu

Gladys Castaño, PhD

Medical Surgical Research Centre, Havana City, Cuba

Ernesto Alvarez, MD

Medical Surgical Research Centre, Havana City, Cuba

Lilia Fernández, PhD

Clinical Pharmacology, National Center for Scientific Research, Havana City, Cuba

Rosa Mas, PhD

Clinical Pharmacology, National Center for Scientific Research, Havana City, Cuba

Sarahí Mendoza, PhD

Clinical Pharmacology, National Center for Scientific Research, Havana City, Cuba

Rafael Gamez, MD

Medical Surgical Research Centre, Havana City, Cuba

Antiplatelet therapy, including aspirin, is recommended to lower the vascular risk in patients with intermittent claudication. Policosanol has increased walking distances in these patients, probably because of its antiplatelet effects, but the effect of shorter treatment has not been studied. This double-blind study compared the effects of policosanol 10 mg/d and aspirin 100 mg/d for 10 weeks on walking distances in claudicants. Thirty-nine patients were randomized to policosanol or aspirin. Walking distances on a treadmill were assessed before and after treatment. Policosanol significantly increased the initial and absolute claudication distances, while aspirin changed neither variable. Policosanol, not aspirin, significantly lowered serum low-density lipoprotein-cholesterol and total cholesterol while raising high-density lipoprotein-cholesterol. In conclusion, treatments of policosanol, not aspirin, for 10 weeks significantly increased walking distances, but modestly, in contrast with previous results. Therefore, the duration of treatments at the doses tested was too short for meaningful effects on the treadmill test.

Key Words: policosanol • aspirin • intermittent claudication • walking distances


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