Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement
Angiology
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0003319707306963v1
59/3/269    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Illnait, J.
Right arrow Articles by Gamez, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Illnait, J.
Right arrow Articles by Gamez, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Effects of Policosanol (10 mg/d) Versus Aspirin (100 mg/d) in Patients With Intermittent Claudication: A 10-Week, Randomized, Comparative Study

José Illnait, PhD

Medical Surgical Research Centre, Havana City, Cuba, clinica{at}enet.cu

Gladys Castaño, PhD

Medical Surgical Research Centre, Havana City, Cuba

Ernesto Alvarez, MD

Medical Surgical Research Centre, Havana City, Cuba

Lilia Fernández, PhD

Clinical Pharmacology, National Center for Scientific Research, Havana City, Cuba

Rosa Mas, PhD

Clinical Pharmacology, National Center for Scientific Research, Havana City, Cuba

Sarahí Mendoza, PhD

Clinical Pharmacology, National Center for Scientific Research, Havana City, Cuba

Rafael Gamez, MD

Medical Surgical Research Centre, Havana City, Cuba

Antiplatelet therapy, including aspirin, is recommended to lower the vascular risk in patients with intermittent claudication. Policosanol has increased walking distances in these patients, probably because of its antiplatelet effects, but the effect of shorter treatment has not been studied. This double-blind study compared the effects of policosanol 10 mg/d and aspirin 100 mg/d for 10 weeks on walking distances in claudicants. Thirty-nine patients were randomized to policosanol or aspirin. Walking distances on a treadmill were assessed before and after treatment. Policosanol significantly increased the initial and absolute claudication distances, while aspirin changed neither variable. Policosanol, not aspirin, significantly lowered serum low-density lipoprotein-cholesterol and total cholesterol while raising high-density lipoprotein-cholesterol. In conclusion, treatments of policosanol, not aspirin, for 10 weeks significantly increased walking distances, but modestly, in contrast with previous results. Therefore, the duration of treatments at the doses tested was too short for meaningful effects on the treadmill test.

Key Words: policosanol • aspirin • intermittent claudication • walking distances

This version was published on July 1, 2008

Angiology, Vol. 59, No. 3, 269-277 (2008)
DOI: 10.1177/0003319707306963
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




Advertisement