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Comparison of Monotherapy Versus Combination Antihypertensive Therapy in Elderly Patients With Essential Hypertension

2nd Department of Internal Medicine, Tzanio General Hospital of Piraeus, Athens

Stelios Kokkoris, MD

2nd Department of Internal Medicine, Tzanio General Hospital of Piraeus, Athens

Styliani Gerakari, MD

2nd Department of Internal Medicine, Tzanio General Hospital of Piraeus, Athens

Sotirios Mikros, MD

2nd Department of Internal Medicine, Tzanio General Hospital of Piraeus, Athens

Thomas Nitsotolis, MD

2nd Department of Internal Medicine, Tzanio General Hospital of Piraeus, Athens

Despina Vikeli, MD

2nd Department of Internal Medicine, Tzanio General Hospital of Piraeus, Athens

Panagiotis Korantzopoulos, MD, PhD

Department of Cardiology, G.Hatzikosta General Hospital of Ioannina, Ioannina Greece, pan-kor{at}mailbox.gr., p.korantzopoulos{at}yahoo.gr

Gregory Giannoulis, MD, PhD

2nd Department of Internal Medicine, Tzanio General Hospital of Piraeus, Athens

Authors sought to compare the efficacy of monotherapy versus combination antihypertensive therapy in elderly patients. Patients in this study, aged 65 to 85 years, were divided into 4 groups and entered an 8-week treatment period. First group: 22 patients, amlodipine 5 mg/d increasing to 10 mg; second: 20 patients, eprosartan 600 mg/d increasing to 600 mg twice a day; third: 21 patients, amlodipine 5 mg/d and indapamide 2.5 mg/d, increasing amlodipine to 10 mg/d; fourth: 23 patients, imidapril 10 mg/d and indapamide 2.5 mg/d, imidapril doubled to 20 mg/d. A greater drop in systolic and in diastolic blood pressure was obtained by combination of amlodipine and indapamide compared with amlodipine or eprosartan monotherapy. Imidapril and indapamide showed similar efficacy compared with eprosartan monotherapy but not with amlodipine monotherapy. Amlodipine and indapamide appeared more effective than imidapril and indapamide in diastolic blood pressure. Combination treatment with amlodipine and indapamide or imidapril and indapamide effectively reduces blood pressure in elderly patients with essential hypertension.

Key Words: hypertension • antihypertensive drugs • elderly • amlodipine • eprosartan • indapamide • imidapril

This version was published on May 1, 2008

Angiology, Vol. 59, No. 2, 230-235 (2008)
DOI: 10.1177/0003319707304580


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