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The Roles of Oxidized Low-Density Lipoprotein and Interleukin-6 Levels in Acute Atherothrombotic and Lacunar Ischemic Stroke

Department of Neurology, Social Security Hospital, Trakya University Medical Faculty

Sibel Guldiken, MD

Department of Endocrinology, Trakya University Medical Faculty, sguldiken{at}trakya.edu.tr

Burhan Turgut, MD

Department of Hematology, Trakya University Medical Faculty

Nilda Turgut, MD

Department of Neurology, Trakya University Medical Faculty, Edirne, Turkey

Muzaffer Demir, MD

Department of Hematology, Trakya University Medical Faculty

Yahya Celik, MD

Department of Neurology, Trakya University Medical Faculty, Edirne, Turkey

Ender Arikan, MD

Department of Endocrinology, Trakya University Medical Faculty

Armagan Tugrul, MD

Department of Endocrinology, Trakya University Medical Faculty

The role of circulating, oxidized low-density lipoprotein and interleukin-6 levels in acute ischemic stroke considering the primary-vessel disease was investigated. The study consisted of 28 patients with acute ischemic stroke and 23 control subjects. Patients were subdivided into large-vessel (n = 12) and small-vessel (n =16) disease stroke groups according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. The means of oxidized low-density lipoprotein and interleukin-6 levels of patients with acute ischemic stroke were higher than controls (P < .01, P < .05). Mean oxidized low-density lipoprotein level was higher in the large-vessel disease group than in the small-vessel disease group (P < .01). The mean of inteleukin-6 levels was higher in the small-vessel disease group (P < .01). The results of the present study showed that oxidative stress promotes large-vessel disease rather than small-vessel disease stroke, and inflammation may play important an role in the development of small-vessel disease stroke.

Key Words: ischemic stroke • oxidized low-density lipoprotein • interleukin-6 • atherosclerosis

This version was published on May 1, 2008

Angiology, Vol. 59, No. 2, 224-229 (2008)
DOI: 10.1177/0003319707304134


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