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Assessment of Early Changes in the Segmental Functions of the Left and the Right Ventricles After Biventricular Pacing in Heart Failure: A Study With Tissue Doppler Imaging

Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Istanbul, Turkey

Beste Ozben, MD

Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Istanbul, Turkey, bestes{at}doctor.com

Tolga Ozyigit, MD

Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Istanbul, Turkey

Deniz Acar, MD

Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Istanbul, Turkey

Dilek Hunerel, MD

Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Istanbul, Turkey

Kamil Adalet, MD

Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Istanbul, Turkey

Yilmaz Nisanci, MD

Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Istanbul, Turkey

Tissue Doppler imaging allows assessment of systolic and diastolic regional ventricular function. The aim of this study was to assess early changes in regional systolic and diastolic functions and differences in transition time to contraction between the ventricles after cardiac resynchronization therapy. Fourteen patients were included, who underwent echocardiography before and 1 month after resynchronization. The difference between transition time to contraction of left and right ventricles decreased to 24.4 ± 10.7 milliseconds from 65.3 ± 18.2 milliseconds after resynchronization therapy (P = .001). There was a significant relation between the decrease in difference between transition time and increase in ejection fraction (r = 0.80, P = .002). Early or late diastolic myocardial motion increased in 7 segments of left and 2 segments of right ventricles. Systolic myocardial motion increased in 7 segments of left and in all segments of right ventricles. Resynchronization therapy improved systolic and diastolic functions in both ventricles. The difference between transition time to contraction of ventricles might be helpful in estimating optimal resynchronization.

Key Words: cardiac resynchronization therapy • multisite cardiac pacing • tissue Doppler imaging • heart failure

This version was published on May 1, 2008

Angiology, Vol. 59, No. 2, 179-184 (2008)
DOI: 10.1177/0003319706291173


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