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Effect of Statins on Serum Apolipoprotein J and Paraoxonase-1 Levels in Patients With Ischemic Heart Disease Undergoing Coronary Angiography

Laboratory for Experimental Surgery and Surgical Research 'N. S. Christeas,' School of Medicine, National and Kapodistrian University of Athens, Greece

Kosmas I. Paraskevas

Department of Clinical Biochemistry (Vascular Disease Prevention Clinic), Royal Free Hospital and Royal Free University College Medical School, University College London, UK, Laboratory for Experimental Surgery and Surgical Research 'N. S. Christeas,' School of Medicine, National and Kapodistrian University of Athens, Greece

Ioannis S. Vlachos

Laboratory for Experimental Surgery and Surgical Research 'N. S. Christeas,' School of Medicine, National and Kapodistrian University of Athens, Greece

Sonia-Athena P. Karabina

INSERM U525, Faculté de Médecine Pitié-Salpetrière, Paris, France

Mark R. Wilson

School of Biological Sciences, University of Wollongong, NSW, Australia

Dimitrios C. Iliopoulos

Laboratory for Experimental Surgery and Surgical Research 'N. S. Christeas,' School of Medicine, National and Kapodistrian University of Athens, Greece, Department of Cardiothoracic Surgery, "Athens Medical Center," Athens, Greece

Serafim I. Tsitsilonis

Laboratory for Experimental Surgery and Surgical Research 'N. S. Christeas,' School of Medicine, National and Kapodistrian University of Athens, Greece

Dimitri P. Mikhailidis

Department of Clinical Biochemistry (Vascular Disease Prevention Clinic), Royal Free Hospital and Royal Free University College Medical School, University College London, UK

Despina N. Perrea

Laboratory for Experimental Surgery and Surgical Research 'N. S. Christeas,' School of Medicine, National and Kapodistrian University of Athens, Greece, dperrea{at}med.uoa.gr

It has been proposed that apolipoprotein J (apo J) and paraoxonase-1 (PON1) correlate with the extent and severity of ischemic heart disease (IHD). This article compares apo J and PON1 serum concentrations, PON1 activity, and the apo J/PON1 ratio in 138 IHD patients (64 statins users and 74 statin nonusers) referred for angiography and possible percutaneous coronary intervention. The effect of statin treatment on apo J and PON1 concentrations, PON1 activity, and the degree of coronary artery stenosis were evaluated. In both groups, apo J levels were increased, whereas PON1 concentration and activity decreased. IHD patients on statins had significantly lower apo J concentration and higher PON1 concentration and activity. Patients on statins had less coronary artery stenosis. High apo J levels, low PON1 levels, low PON1 activity, and a high apo J/PON1 ratio were associated with IHD. Statin treatment reverses these changes, probably by multiple beneficial actions.

Key Words: apolipoprotein J • ischemic heart disease • paraoxonase-1 • statins

Angiology, Vol. 59, No. 2, 137-144 (2008)
DOI: 10.1177/0003319707311722


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