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Coronary Artery Disease in Young Women and Men With Long-Standing Insulin-dependent Diabetes

University of Minnesota, Minneapolis, Minnesota

Tyson Rogers, MS

University of Minnesota, Minneapolis, Minnesota

Bert Kasiske, MD

University of Minnesota, Minneapolis, Minnesota

Stefan Bertog, MD

University of Minnesota, Minneapolis, Minnesota

George Tadros, MD

North Memorial Hospital, Robbinsdale, Minnesota

Jamil Malik, MD

United States Army, stationed in El Paso, Texas

Robert Wilson, MD

University of Minnesota, Minneapolis, Minnesota

Carmelo Panetta, MD

University of Minnesota, Minneapolis, Minnesota, Park Nicollet Health Services, St Louis Park, Minnesota, panet002{at}umn.edu

The prevalence and predictors of coronary artery disease were examined in people aged 40 years and younger with insulin-dependent diabetes mellitus. Analysis was performed on those who presented between 1999 and 2003 for kidney and/or pancreas transplant at the University of Minnesota, as all patients who have diabetes mellitus are required to have perioperative cardiology evaluation. The mean age was 33.5 ± 4.4 years for 88 subjects, all had insulin-dependent diabetes mellitus, and 33% were dialysis dependent. Severe coronary artery disease was found in 18.2% of women and in 24.2% of men. Three-vessel coronary artery disease trended less in women (9.1%) compared with men (12.1%). Multivariate predictors for severe and 3-vessel coronary artery disease included prior coronary artery disease, hypertension duration, and ST-T wave changes on electrocardiogram. Coronary artery disease is twice as high as expected in young woman. Studies on early management for atherosclerosis are warranted in this high-risk population.

Key Words: young people • insulin-dependent diabetes mellitus • coronary artery disease

Angiology, Vol. 59, No. 1, 9-15 (2008)
DOI: 10.1177/0003319707304579


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