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Levo-Propionyl-Carnitine Improves the Effectiveness of Supervised Physical Training on the Absolute Claudication Distance in Patients With Intermittent Claudication

Giuseppe Maria Andreozzi, MD

Angiology Care Unit of University Hospital of Padua, Italy, gm.andreozzi{at}angio-pd.it

Alfredo Leone, MD

Vascular Rehabilitation Unit of Rehabilitation Clinic "Casa di Cura Carmide" Catania, Italy

Rita Laudani, MD

Vascular Rehabilitation Unit of Rehabilitation Clinic "Casa di Cura Carmide" Catania, Italy

Romeo Martin, MM

Angiology Care Unit of University Hospital of Padua, Italy

Gregorio Deinit, MM

Vascular Rehabilitation Unit of Rehabilitation Clinic "Casa di Cura Carmide" Catania, Italy

Valentina Cataldi, MD

Angiology Care Unit of University Hospital of Padua, Italy

The mechanisms by which supervised physical training improves walking ability in patients with intermittent claudication (IC) are microcirculatory, rheological, and metabolic. The main mechanism of levo-propionylcarnitine (LPC) is metabolic; it increases the walking ability in claudicants, providing an additional energy to the ischemic muscle by an anaplerotic activity. Therefore, the current study was carried out to ascertain whether the combined treatment has a synergistic effect. The results confirm the effectiveness of supervised physical training in patients with IC, and we recommend the use of LPC during the exercise training program, at least in patients with severe claudication. Finally, underlining the similar mechanisms of physical training and LPC treatment, the study suggests that a cycle of LPC infusions could be advised in patients with severe claudication who cannot be included, for various reasons, in an exercise rehabilitation program.

Key Words: intermittent claudication • levo-propionylcarnitine • supervised physical training

Angiology, Vol. 59, No. 1, 84-89 (2008)
DOI: 10.1177/0003319707304567
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