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Angiology
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Isosorbide Dinitrate Spray as Therapeutic Strategy for Treatment of Chronic Venous Ulcers

Rene Sánchez-Vázquez, PhD

Unidad de Investigación Cardiovascular, CUCS, Universitdad de Guadalajara

G. Briseño-Rodríguez, MD

Unidad de Investigación Cardiovascular, CUCS, Universitdad de Guadalajara

Ernesto German Cardona-Muñoz, MD

Unidad de Investigación Cardiovascular, CUCS, Universitdad de Guadalajara

Francisco Javier Gálvez-Gastélum, PhD

Instituto de Biología Molecular en Medicina, Universidad de Guadalajara, Guadalajara, Jalisco, México, galvez_gastelum_{at}hotmail.com

Silvia Elena Totsuka-Sutto, MD

Unidad de Investigación Cardiovascular, CUCS, Universitdad de Guadalajara

Leonel Garcia-Benavides, PhD

Unidad de Investigación Cardiovascular, CUCS, Universitdad de Guadalajara, Instituto de Biología Molecular en Medicina, Universidad de Guadalajara, Guadalajara, Jalisco, México

Venous ulcers are the most common form of leg ulcers, which induce lesion because of the loss of substances deposited on the damaged skin. Isosorbide dinitrate is a vasodilator with effects on both arteries and veins and induces opening of vascular layers. The objective is to study the effects of isosorbide dinitrate-spray in patients with chronic venous ulcers. Forty-five patients of both sexes with chronic venous ulcers were randomized to receive isosorbide dinitrate or placebo sprays daily for 3 months. The ulcers were measured and clinical characteristics were taken every 15 days during the treatment. Patients treated with isosorbide dinitrate showed an improvement of the ulcerated area (71.29%) compared with patients treated with placebo (54.35%). The histopathological study indicated an increment in the number of hypertrophic and hyperplasic capillaries. Macroscopically, the isosorbide dinitrate-treatment showed the best results, but it was only during the first 6 weeks of treatment. Patients with chronic venous ulcer receiving isosorbide dinitrate spray showed improvement.

Key Words: ulceration • hypertension • vasodilator • nitric oxide

Angiology, Vol. 59, No. 1, 64-71 (2008)
DOI: 10.1177/0003319707303700
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