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Impaired Flow-Mediated Endothelium-Dependent and Endothelium-Independent Vasodilation of the Brachial Artery in Patients With Atherosclerotic Peripheral Vascular Disease

Department of Cardiovascular Surgery, Saiseikai Wakayama Hospital, komai-ths{at}umin.ac.jp

Yayoi Higami

Department of Clinical Laboratory Saiseikai Wakayama Hospital

Hisaharu Tanaka

Department of Clinical Laboratory Saiseikai Wakayama Hospital

Kentaro Honda, MD

Department of Cardiovascular Surgery, Saiseikai Wakayama Hospital

Masanobu Juri, MD

Department of Cardiovascular Surgery, Saiseikai Wakayama Hospital

Yoshitaka Okamura, MD

Department of Thoracic and Cardiovascular Surgery Wakayama Medical University, Wakayama, Japan

A flow-mediated endothelium-dependent vasodilation and endothelium-independent nitroglycerin-induced vasodilation were carried out in 70 patients and 15 age-matched adults without any atherosclerotic risk factors to clarify vascular responsiveness in patients with atherosclerotic peripheral vascular disease. The percent change in flow-mediated vasodilation was significantly lower in patients than in controls (5.4 ± 0.7% vs 12.8 ± 2.2%, P < .001). Moreover, the percent change in nitroglycerin-induced vasodilation measured after sublingual administration of nitroglycerin was lower in patients than in controls (5.8 ± 0.6% vs 10.2 ± 1.5%, P < .01). On multiple regression analysis, none of the determinant factors showed a significant correlation with flow-mediated vasodilation. In contrast, Fontaine classification was found to be a significant predictor for nitroglycerin-induced vasodilation (r = –0.307, P < .05). There is a significant positive correlation between nitroglycerin-induced vasodilation and ankle-brachial pressure index in the patients. The data showed that vasoditation function were markedly impaired in end-stage patients with peripheral vascular disease.

Key Words: flow-mediated endothelium-dependent vasodilation • endothelium-independent nitroglycerin-induced vasodilation • peripheral vascular disease

Angiology, Vol. 59, No. 1, 52-56 (2008)
DOI: 10.1177/0003319707303442


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